Involvement of opioid receptors in the CGRP-induced antinociception in   the nucleus accumbens of rats

doi:10.1016/j.brainres.2010.07.042

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	Involvement of opioid receptors in the CGRP-induced antinociception in the nucleus accumbens of rats
	Li, Lixin ; Wang, Xuebing ; Yu, Long-Chuan
刊名	脑研究
	2010
关键词	Calcitonin gene-related peptide Nucleus accumbens Hindpaw withdrawal latency Antinociception mu-opioid receptor delta-opioid receptor kappa-opioid receptor GENE-RELATED PEPTIDE SPINAL DORSAL-HORN NEUROPEPTIDE-Y PERIAQUEDUCTAL GRAY INTACT RATS NOCICEPTION PAIN INFLAMMATION AMYGDALA ANTAGONIST
DOI	10.1016/j.brainres.2010.07.042
英文摘要	It has been demonstrated that calcitonin gene-related peptide (CGRP) plays important roles in the modulation of nociception in the nucleus accumbens (NAc) of rats. The present study is performed to explore the possible involvement of opioid receptors in the CGRP-induced antinociception in the NAc of rats. Intra-NAc administration of CGRP induces significant increases in the hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation in rats. Interestingly, the CGRP-induced antinociceptive effects are inhibited by following intra-NAc injection of the opioid receptor antagonist naloxone, suggesting that the opioid receptors are involved in the CGRP-induced antinociception in the NAc of rats. Furthermore, the CGRP-induced antinociception is attenuated by intra-NAc injection of muopioid receptor (MOR) antagonist beta-funaltrexamine (beta-FNA) and kappa-opioid receptor (KOR) antagonist nor-binaltorphimine (nor-BNI), but not by delta-receptor (DOR) antagonist naltrindole. In the present study, we also demonstrated that there was no significant difference between the CGRP-induced antinociception and the morphine-induced antinociception in the NAc in rats. The results of the present study demonstrate that both mu- and kappa-opioid receptors are involved in the CGRP-induced antinociception in the NAc of rats. (C) 2010 Elsevier B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000282419500005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Neurosciences; SCI(E); PubMed; 8; ARTICLE; 53-59; 1353
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162549]
专题	生命科学学院
推荐引用方式 GB/T 7714	Li, Lixin,Wang, Xuebing,Yu, Long-Chuan. Involvement of opioid receptors in the CGRP-induced antinociception in the nucleus accumbens of rats[J]. 脑研究,2010.
APA	Li, Lixin,Wang, Xuebing,&Yu, Long-Chuan.(2010).Involvement of opioid receptors in the CGRP-induced antinociception in the nucleus accumbens of rats.脑研究.
MLA	Li, Lixin,et al."Involvement of opioid receptors in the CGRP-induced antinociception in the nucleus accumbens of rats".脑研究 (2010).