RCOR2 Is a Subunit of the LSD1 Complex That Regulates ESC Property and   Substitutes for SOX2 in Reprogramming Somatic Cells to Pluripotency

doi:10.1002/stem.634

CORC > 北京大学 > 生命科学学院

	RCOR2 Is a Subunit of the LSD1 Complex That Regulates ESC Property and Substitutes for SOX2 in Reprogramming Somatic Cells to Pluripotency
	Yang, Peng ; Wang, Yixuan ; Chen, Jiayu ; Li, Hong ; Kang, Lan ; Zhang, Yu ; Chen, She ; Zhu, Bing ; Gao, Shaorong
刊名	stem cells
	2011
关键词	Histone demethylase Rcor2 Pluripotency Reprogramming EMBRYONIC STEM-CELLS GENE-EXPRESSION DEVELOPMENTAL REGULATORS HISTONE DEACETYLASE INTERACTION NETWORK HUMAN FIBROBLASTS DEFINED FACTORS MOUSE EMBRYOS DIFFERENTIATION GENERATION
DOI	10.1002/stem.634
英文摘要	Histone demethylase LSD1 can form complex with different Rcor family corepressors in different cell types. It remains unknown if cell-specific Rcor proteins function specifically in distinct cell types. Here, we report that Rcor2 is predominantly expressed in ESCs and forms a complex with LSD1 and facilitates its nucleosomal demethylation activity. Knockdown of Rcor2 in ESCs inhibited ESC proliferation and severely impaired the pluripotency. Moreover, knockdown of Rcor2 greatly impaired the formation of induced pluripotent stem (iPS) cells. In contrast, ectopic expression of Rcor2 in somatic cells together with Oct4, Sox2, and Klf4 promoted the formation of iPS cells. Most interestingly, ectopic expression of Rcor2 in both mouse and human somatic cells effectively substituted the requirement for exogenous Sox2 expression in somatic cell reprogramming. STEM CELLS 2011;29:791-801; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000289719200007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Oncology; Cell Biology; Hematology; SCI(E); PubMed; 32; ARTICLE; 5; 791-801; 29
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162540]
专题	生命科学学院
推荐引用方式 GB/T 7714	Yang, Peng,Wang, Yixuan,Chen, Jiayu,et al. RCOR2 Is a Subunit of the LSD1 Complex That Regulates ESC Property and Substitutes for SOX2 in Reprogramming Somatic Cells to Pluripotency[J]. stem cells,2011.
APA	Yang, Peng.,Wang, Yixuan.,Chen, Jiayu.,Li, Hong.,Kang, Lan.,...&Gao, Shaorong.(2011).RCOR2 Is a Subunit of the LSD1 Complex That Regulates ESC Property and Substitutes for SOX2 in Reprogramming Somatic Cells to Pluripotency.stem cells.
MLA	Yang, Peng,et al."RCOR2 Is a Subunit of the LSD1 Complex That Regulates ESC Property and Substitutes for SOX2 in Reprogramming Somatic Cells to Pluripotency".stem cells (2011).