Halothane increases neuronal cell death vulnerability by downregulating   miR-214 and upregulating Bax

CORC > 北京大学 > 生命科学学院

	Halothane increases neuronal cell death vulnerability by downregulating miR-214 and upregulating Bax
	Zhang, Lei ; Zhang, Yan
刊名	international journal of clinical and experimental medicine
	2013
关键词	Halothane miR-214 Bax cell death Alzheimer&apos ISOFLURANE INDUCES APOPTOSIS NITROUS OXIDE ANESTHESIA AMYLOID PROTEIN-LEVELS ALZHEIMERS-DISEASE GENERAL-ANESTHESIA BETA PEPTIDE AGED RATS CYTOTOXICITY TAU HYPERPHOSPHORYLATION s disease
英文摘要	Inhalational general anesthesia is widely used in clinical practice, but there have been plenty of evidence shows that application of inhalational anesthetics may increase the risk of Alzheimer's disease (AD). Halothane is a common inhalational anesthetics. We cultured rat primary neurons as study model to investigate cytotoxicity of halothane in neurons. We found that halothane could enhance the cytotoxicity induced by intracellular or extracellular amyloid beta (A beta) with or without serum deprivation. In addition, halothane induced the enhanced cytotoxicity through downregulation of miR-214 level which can lead to increasing expression of Bax. Therefore our data suggest that halothane increases cell death induced by A beta through increasing Bax level by downregulating miR-214. Our study indicates a probable connection between anesthetic application and AD, while provides a new perspective for the studies of inhalational anesthetics cytotoxicity.; Medicine, Research & Experimental; SCI(E); PubMed; 1; ARTICLE; 6; 452-460; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162491]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhang, Lei,Zhang, Yan. Halothane increases neuronal cell death vulnerability by downregulating miR-214 and upregulating Bax[J]. international journal of clinical and experimental medicine,2013.
APA	Zhang, Lei,&Zhang, Yan.(2013).Halothane increases neuronal cell death vulnerability by downregulating miR-214 and upregulating Bax.international journal of clinical and experimental medicine.
MLA	Zhang, Lei,et al."Halothane increases neuronal cell death vulnerability by downregulating miR-214 and upregulating Bax".international journal of clinical and experimental medicine (2013).