Morphogenesis of T-tubules in heart cells: the role of junctophilin-2

doi:10.1007/s11427-013-4490-4

CORC > 北京大学 > 生命科学学院

	Morphogenesis of T-tubules in heart cells: the role of junctophilin-2
	Han Jing ; Wu HaoDi ; Wang QiWei ; Wang ShiQiang
刊名	science china life sciences
	2013
关键词	T-tubules junctophilin-2 cardiomyocytes morphogenesis RYANODINE RECEPTORS FAILING HEART CA2+ RELEASE RAT MYOCYTES CARDIOMYOCYTES TRANSIENTS BIOLOGY MUSCLES SPARKS
DOI	10.1007/s11427-013-4490-4
英文摘要	The T-tubule (TT) system forms the structural basis for excitation-contraction coupling in heart and muscle cells. The morphogenesis of the TT system is a key step in the maturation of heart cells because it does not exist in neonatal cardiomyocytes. In the present study, we quantified the morphological changes in TTs during heart cell maturation and investigated the role of junctophilin-2 (JP2), a protein known to anchor the sarcoplasmic reticulum (SR) to TT, in changes to TT morphological parameters. Analysis of confocal images showed that the transverse elements of TTs increased, while longitudinal elements decreased during the maturation of TTs. Fourier transform analysis showed that the power of similar to 2 mu m spatial components increased with cardiomyocytes maturation. These changes were preceded by increased expression of JP2, and were reversed by JP2 knockdown. These findings indicate that JP2 is required for the morphogenesis of TTs during heart development.; Biology; SCI(E); PubMed; 2; ARTICLE; 7; 647-652; 56
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162476]
专题	生命科学学院
推荐引用方式 GB/T 7714	Han Jing,Wu HaoDi,Wang QiWei,et al. Morphogenesis of T-tubules in heart cells: the role of junctophilin-2[J]. science china life sciences,2013.
APA	Han Jing,Wu HaoDi,Wang QiWei,&Wang ShiQiang.(2013).Morphogenesis of T-tubules in heart cells: the role of junctophilin-2.science china life sciences.
MLA	Han Jing,et al."Morphogenesis of T-tubules in heart cells: the role of junctophilin-2".science china life sciences (2013).