Intra-nucleus accumbens administration of the   calcium/calmodulin-dependent protein kinase II inhibitor KN93 induced   antinociception in rats with mononeuropathy

doi:10.1016/j.neulet.2014.09.007

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	Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor KN93 induced antinociception in rats with mononeuropathy
	Bian, Hui ; Yu, Long-Chuan
刊名	神经科学快报
	2014
关键词	Antinociceptive effect Calcium/calmodulin-dependent protein kinase II (CaMKII) Hindpaw withdrawal latency Mononeuropathy KN93 Nucleus accumbens PAIN-RELATED BEHAVIOR SPINAL-CORD PERIAQUEDUCTAL GREY OPIOID RECEPTORS NEUROPATHIC PAIN ARCUATE NUCLEUS INVOLVEMENT EXPRESSION GALANIN ALPHA
DOI	10.1016/j.neulet.2014.09.007
英文摘要	The present study was conducted on rats with mononeuropathy induced by left common sciatic nerve ligation. Unilateral sciatic nerve loose ligation produced decreases of the hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation. Intra-nucleus accumbens (NAc) injection of 1 mu g, 3 mu g and 6 mu g of KN93, the calcium/calmodulin-dependent protein kinase II (CaMKII) inhibitor, dose-dependently increased the HWL in mononeuropathic rats. Furthermore, intra-NAc administration of morphine, the HWL to noxious thermal and mechanical stimulation increased markedly, and there were no significant differences between morphine group and KN93 group. The results demonstrated that intra-NAc injection of KN93 induced significant antinociceptive effects in rats with mononeuropathy, indicating CaMKII may play important roles in transmission of nociceptive information in the NAc of mononeuropathic rats. (C) 2014 Elsevier Ireland Ltd. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000345604300002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Neurosciences; SCI(E); PubMed; 2; ARTICLE; yulc@pku.edu.cn; 6-10; 583
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162440]
专题	生命科学学院
推荐引用方式 GB/T 7714	Bian, Hui,Yu, Long-Chuan. Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor KN93 induced antinociception in rats with mononeuropathy[J]. 神经科学快报,2014.
APA	Bian, Hui,&Yu, Long-Chuan.(2014).Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor KN93 induced antinociception in rats with mononeuropathy.神经科学快报.
MLA	Bian, Hui,et al."Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor KN93 induced antinociception in rats with mononeuropathy".神经科学快报 (2014).