Proline Isomerization of the Immune Receptor-Interacting Protein RIN4 by   a Cyclophilin Inhibits Effector-Triggered Immunity in Arabidopsis

doi:10.1016/j.chom.2014.09.007

CORC > 北京大学 > 生命科学学院

	Proline Isomerization of the Immune Receptor-Interacting Protein RIN4 by a Cyclophilin Inhibits Effector-Triggered Immunity in Arabidopsis
	Li, Meng ; Ma, Xiqing ; Chiang, Yi-Hsuan ; Yadeta, Koste A. ; Ding, Pengfei ; Dong, Liansai ; Zhao, Yan ; Li, Xiuming ; Yu, Yufei ; Zhang, Ling ; Shen, Qian-Hua ; Xia, Bin ; Coaker, Gitta ; Liu, Dong ; Zhou, Jian-Min
刊名	cell host microbe
	2014
关键词	NUCLEOTIDE-BINDING SITE PSEUDOMONAS-SYRINGAE DISEASE RESISTANCE III EFFECTOR RESPONSIVE CYCLOPHILIN MOLECULAR-BASIS CYCLOSPORINE-A HOST TARGET PLANT GENE
DOI	10.1016/j.chom.2014.09.007
英文摘要	In the absence of pathogen infection, plant effector-triggered immune (ETI) receptors are maintained in a preactivation state by intermolecular interactions with other host proteins. Pathogen effector-induced alterations activate the receptor. In Arabidopsis, the ETI receptor RPM1 is activated via bacterial effector AvrB-induced phosphorylation of the RPM1-interacting protein RIN4 at Threonine 166. We find that RIN4 also interacts with the prolyl-peptidyl isomerase (PPIase) ROC1, which is reduced upon RIN4 Thr166 phosphorylation. ROC1 suppresses RPM1 immunity in a PPIase-dependent manner. Consistent with this, RIN4 Pro149 undergoes cis/trans isomerization in the presence of ROC1. While the RIN4(P149V) mutation abolishes RPM1 resistance, the deletion of Pro149 leads to RPM1 activation in the absence of RIN4 phosphorylation. These results support a model in which RPM1 directly senses conformational changes in RIN4 surrounding Pro149 that is controlled by ROC1. RIN4 Thr166 phosphorylation indirectly regulates RPM1 resistance by modulating the ROC1-mediated RIN4 isomerization.; Microbiology; Parasitology; Virology; SCI(E); PubMed; 2; ARTICLE; liu-d@mail.tsinghua.edu.cn; jmzhou@genetics.ac.cn; 4; 473-483; 16
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162438]
专题	生命科学学院
推荐引用方式 GB/T 7714	Li, Meng,Ma, Xiqing,Chiang, Yi-Hsuan,et al. Proline Isomerization of the Immune Receptor-Interacting Protein RIN4 by a Cyclophilin Inhibits Effector-Triggered Immunity in Arabidopsis[J]. cell host microbe,2014.
APA	Li, Meng.,Ma, Xiqing.,Chiang, Yi-Hsuan.,Yadeta, Koste A..,Ding, Pengfei.,...&Zhou, Jian-Min.(2014).Proline Isomerization of the Immune Receptor-Interacting Protein RIN4 by a Cyclophilin Inhibits Effector-Triggered Immunity in Arabidopsis.cell host microbe.
MLA	Li, Meng,et al."Proline Isomerization of the Immune Receptor-Interacting Protein RIN4 by a Cyclophilin Inhibits Effector-Triggered Immunity in Arabidopsis".cell host microbe (2014).