三叶因子家族

doi:10.3321/j.issn:1000-3282.2000.04.010

CORC > 北京大学 > 生命科学学院

	三叶因子家族; Trefoil factor family.
	口如琴 ; 王蔚 ; 李令媛 ; 茹炳根
刊名	生物化学与生物物理进展
	2000
关键词	三叶因子家族表达位点结构功能作用机理 trefoil factor family expression sites structure function mechanism
DOI	10.3321/j.issn:1000-3282.2000.04.010
英文摘要	三叶因子家族是一类具有特殊结构———P结构域的蛋白质家族 ,P结构域包含 6个高度保守的半胱氨酸残基及精氨酸、甘氨酸、色氨酸和苯丙氨酸残基 .半胱氨酸残基以Cys1 Cys5 ,Cys2 Cys4,Cys3 Cys6连接形成三个链内二硫桥 .已发现多种含有P结构域的多肽 ,其中最引人注目的是TFF1/pS2、TFF2 /SP及TFF3/ITF ,在正常组织中其主要表达位点分别为胃基底和胃体 (TFF1/pS2 )、胃窦深部的小凹 (TFF2 /SP)及小肠和大肠杯状细胞 (TFF3/ITF) .TFF可能具有维持粘膜屏障和促进溃疡治愈的功能 .TFF含有α折叠 (α helix) ,β片层 ...; Trefoil factor family (TFF) peptides have a special domain called trefoil domain. Trefoil domain contains highly conserved cysteine, arginine, glycine, tryptophane, phenylalanine and a unique three-loop structure which is formed by intrachain disulfide bonds between six conserved cysteine residues in the 1 similar to5, 2 similar to4, 3 similar to6 position. Three most important TFF peptides are TFF1/pS2, TFF2/SP (spasmolytic polypeptide) and TFF3/ITF (intestinal trefoil factor). The ectopically expressed sites of them are body and fundus of stomach, deep foveolar pits of gastric antrum and goblet cell of small and large intestine, respectively. TFF may play an important role in both maintaining the barrier function of mucosal surfaces and facilitating healing after injury. The structures of TFF peptides are very compact and contain alpha -helix, beta -sheet. The mechanism of TFF is not clear and two hypotheses were proposed which were co-working with mucin or receptor.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000165287300009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; SCI(E); 中文核心期刊要目总览(PKU); 中国科学引文数据库(CSCD); 1; 04; 367-372; 27
语种	中文
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/45915]
专题	生命科学学院
推荐引用方式 GB/T 7714	口如琴,王蔚,李令媛,等. 三叶因子家族, Trefoil factor family.[J]. 生物化学与生物物理进展,2000.
APA	口如琴,王蔚,李令媛,&茹炳根.(2000).三叶因子家族.生物化学与生物物理进展.
MLA	口如琴,et al."三叶因子家族".生物化学与生物物理进展 (2000).