Ligand-Assisted Palladium(II)/(IV) Oxidation for sp(3) CH Fluorination | |
Sun, Huan ; Zhang, Yi ; Chen, Ping ; Wu, Yun-Dong ; Zhang, Xinhao ; Huang, Yong | |
刊名 | ADVANCED SYNTHESIS & CATALYSIS |
2016 | |
关键词 | CH activation directing group fluorination oxidation palladium UNACTIVATED C(SP(3))-H BONDS ALPHA-AMINO-ACIDS CARBON-HYDROGEN BONDS FORMING REDUCTIVE ELIMINATION TRANSITION-METAL-COMPLEXES H BONDS CATALYZED ARYLATION STEREOSELECTIVE-SYNTHESIS ARYLBORON REAGENTS C(SP(2))-H BONDS |
DOI | 10.1002/adsc.201600015 |
英文摘要 | The direct functionalization of inert sp(3) CH bonds is limited to a few bond types. Although the activation of sp(3) CH bonds can be accomplished under mild conditions using palladium catalysts, the subsequent functionalization is not trivial due to the high energy required to convert palladium(II) to palladium(IV). We have systematically studied the palladium oxidation using computation-guided experiments for reactions involving strong chelation control. We find that a mild external ligand could significantly accelerate the oxidation of palladium(II) to palladium(IV) for strong bidentate directing groups. The acceleration is believed to be a result of ligand stabilization of both the palladium(II) and palladium(IV) intermediates.; National Natural Science Foundation of China [21372013, 21572004, 21133002, 21232001]; Shenzhen Peacock Program [KQTD201103]; Shenzhen innovation funds [CXZZ20130517152257071]; SCI(E); ARTICLE; wuyd@pkusz.edu.cn; zhangxh@pkusz.edu.cn; huangyong@pkusz.edu.cn; 12; 1946-1957; 358 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/492164] |
专题 | 化学与分子工程学院 |
推荐引用方式 GB/T 7714 | Sun, Huan,Zhang, Yi,Chen, Ping,et al. Ligand-Assisted Palladium(II)/(IV) Oxidation for sp(3) CH Fluorination[J]. ADVANCED SYNTHESIS & CATALYSIS,2016. |
APA | Sun, Huan,Zhang, Yi,Chen, Ping,Wu, Yun-Dong,Zhang, Xinhao,&Huang, Yong.(2016).Ligand-Assisted Palladium(II)/(IV) Oxidation for sp(3) CH Fluorination.ADVANCED SYNTHESIS & CATALYSIS. |
MLA | Sun, Huan,et al."Ligand-Assisted Palladium(II)/(IV) Oxidation for sp(3) CH Fluorination".ADVANCED SYNTHESIS & CATALYSIS (2016). |
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