Chemical Modifications to RNA: A New Layer of Gene Expression Regulation

doi:10.1021/acschembio.6b00960

CORC > 北京大学 > 化学与分子工程学院

	Chemical Modifications to RNA: A New Layer of Gene Expression Regulation
	Song, Jinghui ; Yi, Chengqi
刊名	ACS CHEMICAL BIOLOGY
	2017
关键词	DYNAMIC N-1-METHYLADENOSINE METHYLOME NUCLEIC-ACID CONFORMATIONS EMBRYONIC STEM-CELLS 25S RIBOSOMAL-RNA MESSENGER-RNA BASE MODIFICATION MAPPING REVEALS MAMMALIAN RNA POSTTRANSCRIPTIONAL MODIFICATIONS SACCHAROMYCES-CEREVISIAE
DOI	10.1021/acschembio.6b00960
英文摘要	The first chemical modification to RNA was discovered nearly 60 years ago; to date, more than 100 chemically distinct modifications have been identified in cellular RNA. With the recent development of novel chemical and/or biochemical methods, dynamic modifications to RNA have been identified in the transcriptome, including N-6-methyladenosine (m(6)A), inosine (I), 5-methylcytosine (m(5)C), pseudouridine (Psi), 5-hydroxymethylcytosine (hm(5)C), and N-1-methyladenosine (m(1)A). Collectively, the multitude of RNA modifications are termed epitranscriptome, leading to the emerging field of epitranscriptomics. In this review, we primarily focus on recently reported chemical modifications to mRNA; we discuss their chemical properties, biological functions, and mechanisms with an emphasis on their high-throughput detection methods. We also envision that future tools, particularly novel chemical biology methods, could further facilitate and enable studies in the field of epitranscriptomics.; National Basic Research Foundation of China [MOST2016YFC0900300]; National Natural Science Foundation of China [21522201]; Beijing Natural Science Foundation [5162012]; SCI(E); REVIEW; 2; 316-325; 12
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/475282]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Song, Jinghui,Yi, Chengqi. Chemical Modifications to RNA: A New Layer of Gene Expression Regulation[J]. ACS CHEMICAL BIOLOGY,2017.
APA	Song, Jinghui,&Yi, Chengqi.(2017).Chemical Modifications to RNA: A New Layer of Gene Expression Regulation.ACS CHEMICAL BIOLOGY.
MLA	Song, Jinghui,et al."Chemical Modifications to RNA: A New Layer of Gene Expression Regulation".ACS CHEMICAL BIOLOGY (2017).