Sequence-based prediction of protein protein interaction using a   deep-learning algorithm

doi:10.1186/s12859-017-1700-2

CORC > 北京大学 > 化学与分子工程学院

	Sequence-based prediction of protein protein interaction using a deep-learning algorithm
	Sun, Tanlin ; Zhou, Bo ; Lai, Luhua ; Pei, Jianfeng
刊名	BMC BIOINFORMATICS
	2017
关键词	Deep learning Protein-protein interaction SUPPORT VECTOR MACHINE NEURAL-NETWORKS SACCHAROMYCES-CEREVISIAE SECONDARY STRUCTURE BINDING HYPERPLANES FEATURES
DOI	10.1186/s12859-017-1700-2
英文摘要	Background: Protein-protein interactions (PPIs) are critical for many biological processes. It is therefore important to develop accurate high-throughput methods for identifying PPI to better understand protein function, disease occurrence, and therapy design. Though various computational methods for predicting PPI have been developed, their robustness for prediction with external datasets is unknown. Deep-learning algorithms have achieved successful results in diverse areas, but their effectiveness for PPI prediction has not been tested. Results: We used a stacked autoencoder, a type of deep-learning algorithm, to study the sequence-based PPI prediction. The best model achieved an average accuracy of 97.19% with 10-fold cross-validation. The prediction accuracies for various external datasets ranged from 87.99% to 99.21%, which are superior to those achieved with previous methods. Conclusions: To our knowledge, this research is the first to apply a deep-learning algorithm to sequence-based PPI prediction, and the results demonstrate its potential in this field.; National Natural Science Foundation of China [21673010, 81273436]; Ministry of Science and Technology of China [2016YFA0502303]; SCI(E); ARTICLE; 18
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/473331]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Sun, Tanlin,Zhou, Bo,Lai, Luhua,et al. Sequence-based prediction of protein protein interaction using a deep-learning algorithm[J]. BMC BIOINFORMATICS,2017.
APA	Sun, Tanlin,Zhou, Bo,Lai, Luhua,&Pei, Jianfeng.(2017).Sequence-based prediction of protein protein interaction using a deep-learning algorithm.BMC BIOINFORMATICS.
MLA	Sun, Tanlin,et al."Sequence-based prediction of protein protein interaction using a deep-learning algorithm".BMC BIOINFORMATICS (2017).