Discovery of a potent and highly specific beta(2) proteasome inhibitor   from a library of copper complexes

doi:10.1016/j.bmcl.2016.10.043

CORC > 北京大学 > 化学与分子工程学院

	Discovery of a potent and highly specific beta(2) proteasome inhibitor from a library of copper complexes
	Zhou, Tongliang ; Cai, Yuanbo ; Liang, Lei ; Yang, Lingfei ; Xu, Fengrong ; Niu, Yan ; Wang, Chao ; Zhang, Jun-Long ; Xu, Ping
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2016
关键词	Proteasome inhibitors Schiff base Copper complex Drug design Structure-activity relationships 20S PROTEASOME CANCER-CELLS PLATINUM COMPOUNDS DRUG DEVELOPMENT SCHIFF-BASES N-ARYLATION APOPTOSIS ANTICANCER INDUCTION UBIQUITIN
DOI	10.1016/j.bmcl.2016.10.043
英文摘要	We reported the synthesis, characterization and biological activity of several copper(II) Schiff base complexes, which exhibit high proteasome inhibitory activities with particular selectivity of beta(2) subunit. Structure-activity relationships information obtained from complex Na-2[Cu(a4s1)] demonstrated that distinct bonding modes in beta(2) and beta(5) subunits determines its selectivity and potent inhibition for beta(2) subunit. (C) 2016 Elsevier Ltd. All rights reserved.; National Natural Science Foundation of China [21202003/21571007/21271013]; Beijing Natural Science Foundation [7162110]; SCI(E); PubMed; ARTICLE; leiliang@bjmu.edu.cn; zhangjl@pku.edu.cn; pingxu@bjmu.edu.cn; 23; 5780-5784; 26
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/457098]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhou, Tongliang,Cai, Yuanbo,Liang, Lei,et al. Discovery of a potent and highly specific beta(2) proteasome inhibitor from a library of copper complexes[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016.
APA	Zhou, Tongliang.,Cai, Yuanbo.,Liang, Lei.,Yang, Lingfei.,Xu, Fengrong.,...&Xu, Ping.(2016).Discovery of a potent and highly specific beta(2) proteasome inhibitor from a library of copper complexes.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.
MLA	Zhou, Tongliang,et al."Discovery of a potent and highly specific beta(2) proteasome inhibitor from a library of copper complexes".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016).