Readily Removable Directing Group Assisted Chemo- and Regioselective   C(sp(3))-H Activation by Palladium Catalysis

doi:10.1002/anie.201505932

CORC > 北京大学 > 化学与分子工程学院

	Readily Removable Directing Group Assisted Chemo- and Regioselective C(sp(3))-H Activation by Palladium Catalysis
	Zhang, Yun-Fei ; Zhao, Hong-Wei ; Wang, Hui ; Wei, Jiang-Bo ; Shi, Zhang-Jie
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2015
关键词	arenes C-H activation palladium silver synthetic methods C-H BOND CARBON-HYDROGEN BONDS CROSS-COUPLING REACTIONS ALPHA-AMINO-ACIDS UNACTIVATED C(SP(3))-H DIRECT ARYLATION STEREOSELECTIVE-SYNTHESIS ORGANIC-SYNTHESIS ROOM-TEMPERATURE NATURAL-PRODUCTS
DOI	10.1002/anie.201505932
英文摘要	Currently used directing groups for selective aliphatic -functionalization of carbonyl compounds show excellent reactivity and selectivity with an amide as a linker. Described herein is 2-piconimide, used for the first time with commercially available 2-picolinamide/2-picolic acid as precursors, to direct CH arylation/alkenylation by palladium catalysis. The directing group is essential for promoting the sequnetial primary and secondary C(sp(3))H arylation with different aryl iodides in one substrate. The directing group was easily removed under simple reaction conditions at room temperature.; "973" Project from MOST of China [2013CB228102, 2015CB856600]; NSFC [21332001]; NSF of Shanxi Province [2014011014-4]; SCI(E); ARTICLE; 46; 13686-13690; 54
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/439247]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhang, Yun-Fei,Zhao, Hong-Wei,Wang, Hui,et al. Readily Removable Directing Group Assisted Chemo- and Regioselective C(sp(3))-H Activation by Palladium Catalysis[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015.
APA	Zhang, Yun-Fei,Zhao, Hong-Wei,Wang, Hui,Wei, Jiang-Bo,&Shi, Zhang-Jie.(2015).Readily Removable Directing Group Assisted Chemo- and Regioselective C(sp(3))-H Activation by Palladium Catalysis.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA	Zhang, Yun-Fei,et al."Readily Removable Directing Group Assisted Chemo- and Regioselective C(sp(3))-H Activation by Palladium Catalysis".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015).