Access to the 2H-Tetrahydro-4,6-dioxo-1,2-oxazine Ring System from   Nitrone via a Tandem Nucleophilic Addition and Transesterification   Reaction

doi:10.1021/acs.orglett.5b03374

CORC > 北京大学 > 化学与分子工程学院

	Access to the 2H-Tetrahydro-4,6-dioxo-1,2-oxazine Ring System from Nitrone via a Tandem Nucleophilic Addition and Transesterification Reaction
	Yang, Shaoqiang ; Liao, Daohong ; Tian, Xiaoqi ; Lei, Xiaoguang
刊名	ORGANIC LETTERS
	2016
关键词	DIELS-ALDER REACTION HETEROCYCLIC NATURAL-PRODUCTS DIASTEREOSELECTIVE ADDITION ASSISTED ALKYNYLATION ALDEHYDES DIENE HYDROXYLAMINES STREPTOMYCES ALCHIVEMYCIN DERIVATIVES
DOI	10.1021/acs.orglett.5b03374
英文摘要	A general and efficient synthesis of the 2H-tetrahydro-4,6-dioxo-1,2-oxazine ring system through a tandem nucleophilic addition and transesterification reaction is described. The reaction is highly functional-group-tolerant and proceeds under mild conditions, affording the corresponding products in good to excellent yields. This method represents the first general synthetic route to access this heterocyclic scaffold, which exists in the complex natural products alchivemycin A and B with significant antibiotic activities.; National High Technology Project 973 [2015CB856200]; NNSFC [21222209, 91313303, 21472010, 21561142002]; SCI(E); ARTICLE; xglei@pku.edu.cn; 3; 376-379; 18
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/438663]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Yang, Shaoqiang,Liao, Daohong,Tian, Xiaoqi,et al. Access to the 2H-Tetrahydro-4,6-dioxo-1,2-oxazine Ring System from Nitrone via a Tandem Nucleophilic Addition and Transesterification Reaction[J]. ORGANIC LETTERS,2016.
APA	Yang, Shaoqiang,Liao, Daohong,Tian, Xiaoqi,&Lei, Xiaoguang.(2016).Access to the 2H-Tetrahydro-4,6-dioxo-1,2-oxazine Ring System from Nitrone via a Tandem Nucleophilic Addition and Transesterification Reaction.ORGANIC LETTERS.
MLA	Yang, Shaoqiang,et al."Access to the 2H-Tetrahydro-4,6-dioxo-1,2-oxazine Ring System from Nitrone via a Tandem Nucleophilic Addition and Transesterification Reaction".ORGANIC LETTERS (2016).