Development and application of bond cleavage reactions in bioorthogonal   chemistry

doi:10.1038/NCHEMBIO.2024

CORC > 北京大学 > 化学与分子工程学院

	Development and application of bond cleavage reactions in bioorthogonal chemistry
	Li, Jie ; Chen, Peng R.
刊名	NATURE CHEMICAL BIOLOGY
	2016
关键词	LIVING CELLS CLICK CHEMISTRY PROTECTING GROUPS GENETIC-CODE TETRAZINE LIGATION FLUORESCENT-PROBE PROTEIN FUNCTION SMALL MOLECULES VISIBLE-LIGHT HUMAN GENOME
DOI	10.1038/NCHEMBIO.2024
英文摘要	Bioorthogonal chemical reactions are a thriving area of chemical research in recent years as an unprecedented technique to dissect native biological processes through chemistry-enabled strategies. However, current concepts of bioorthogonal chemistry have largely centered on 'bond formation' reactions between two mutually reactive bioorthogonal handles. Recently, in a reverse strategy, a collection of 'bond cleavage' reactions has emerged with excellent biocompatibility. These reactions have expanded our bioorthogonal chemistry repertoire, enabling an array of exciting new biological applications that range from the chemically controlled spatial and temporal activation of intracellular proteins and small-molecule drugs to the direct manipulation of intact cells under physiological conditions. Here we highlight the development and applications of these bioorthogonal cleavage reactions. Furthermore, we lay out challenges and propose future directions along this appealing avenue of research.; National Natural Science Foundation of China [21225206, 21521003, 21432002]; National Basic Research Program of China [2012C0917301]; SCI(E); ARTICLE; pengchen@pku.edu.cn; 3; 129-137; 12
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/438569]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Li, Jie,Chen, Peng R.. Development and application of bond cleavage reactions in bioorthogonal chemistry[J]. NATURE CHEMICAL BIOLOGY,2016.
APA	Li, Jie,&Chen, Peng R..(2016).Development and application of bond cleavage reactions in bioorthogonal chemistry.NATURE CHEMICAL BIOLOGY.
MLA	Li, Jie,et al."Development and application of bond cleavage reactions in bioorthogonal chemistry".NATURE CHEMICAL BIOLOGY (2016).