Synthesis and radiolabeling of Cu-64-labeled 2-nitroimidazole derivative   Cu-64-BMS2P2 for hypoxia imaging

doi:10.1016/j.bmcl.2016.01.077

CORC > 北京大学 > 化学与分子工程学院

	Synthesis and radiolabeling of Cu-64-labeled 2-nitroimidazole derivative Cu-64-BMS2P2 for hypoxia imaging
	Luo, Zheng ; Zhu, Hua ; Lin, Xinfeng ; Chu, Taiwei ; Luo, Ruyi ; Wang, Yunhua ; Yang, Zhi
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2016
关键词	Hypoxia imaging Copper-64 2-Nitroimidazole Carbonic anhydrase 9 Positron emission tomography SQUAMOUS-CELL CARCINOMA RADIATION-THERAPY PET CANCER HEAD COMPLEXES
DOI	10.1016/j.bmcl.2016.01.077
英文摘要	The objective of this study was to develop a positron emission tomography (PET) probe with hypoxia targeting specificity and a relatively long half-life. The synthesis, Cu-64-labeling in vitro and in vivo study of the novel 2-nitroimidazole complex Cu-64-BMS2P2 is presented in this study. The hypoxia targeting capacity of Cu-64-BMS2P2 in vitro was evaluated and compared with the Cu-64-BMS181321, and confirmed by PET imaging in vivo and immunohistochemistry for carbonic anhydrase 9 (CA9) in a tumor mouse model. These results suggest that Cu-64-BMS2P2 is a promising candidate for PET hypoxia imaging and worthy of further investigations in dynamic hypoxia imaging. (C) 2016 Elsevier Ltd. All rights reserved.; National Natural Science Foundation of China [81071198, 81172082, 81371592]; Beijing Natural Science Foundation [7132040]; SCI(E); PubMed; ARTICLE; 13973186448@139.com; pekyz@163.com; 5; 1397-1400; 26
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/435014]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Luo, Zheng,Zhu, Hua,Lin, Xinfeng,et al. Synthesis and radiolabeling of Cu-64-labeled 2-nitroimidazole derivative Cu-64-BMS2P2 for hypoxia imaging[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016.
APA	Luo, Zheng.,Zhu, Hua.,Lin, Xinfeng.,Chu, Taiwei.,Luo, Ruyi.,...&Yang, Zhi.(2016).Synthesis and radiolabeling of Cu-64-labeled 2-nitroimidazole derivative Cu-64-BMS2P2 for hypoxia imaging.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.
MLA	Luo, Zheng,et al."Synthesis and radiolabeling of Cu-64-labeled 2-nitroimidazole derivative Cu-64-BMS2P2 for hypoxia imaging".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016).