Study on clarithromycin lactobionate based dual selector systems for the   enantioseparation of basic drugs in capillary electrophoresis

doi:10.1002/jssc.201400677

CORC > 北京大学 > 化学与分子工程学院

	Study on clarithromycin lactobionate based dual selector systems for the enantioseparation of basic drugs in capillary electrophoresis
	Yu, Tao ; Du, Yingxiang ; Chen, Jiaquan ; Xu, Guangfu ; Yang, Ke ; Zhang, Qi ; Zhang, Jinjing ; Du, Shuaijing ; Feng, Zijie ; Zhang, Yanjie
刊名	JOURNAL OF SEPARATION SCIENCE
	2015
关键词	Capillary electrophoresis Clarithromycin lactobionate Cyclodextrin Dual chiral system Enantioseparation HYDROXYPROPYL-BETA-CYCLODEXTRIN CHIRAL IONIC LIQUIDS ENANTIOMERIC SEPARATION CHROMATOGRAPHY DERIVATIVES ENANTIOSELECTIVITY POLYSACCHARIDES ANTIBIOTICS VANCOMYCIN ADDITIVES
DOI	10.1002/jssc.201400677
英文摘要	In this paper, the use of clarithromycin lactobionate, a kind of antibiotic chiral selector, in combination with four neutral cyclodextrin derivatives (glucose-beta-cyclodextrin, hydroxyethyl-beta-cyclodextrin, methyl-beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin) was reported for the first time. As a result, these dual systems gave much better resolution of nefopam (the Rs increased to 3.58, 2.72, 1.49 and 1.42, respectively) compared to the single systems. The effects of buffer pH and selector concentration on the separation of nefopam were also investigated. Additionally, some other basic drugs including metoprolol, atenolol, propranolol, bisoprolol, esmolol and ritodrine were tested for the investigation and evaluation of the enantiorecognition capability of the four dual systems. As expected, the synergistic effect was observed in four systems. Different results of these dual systems were also summarized.; National Natural Science Foundation of China [81072610]; Fundamental Research Funds for the Central Universities [PY2014LX0014]; Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD); SCI(E); EI; PubMed; ARTICLE; du_yingxiang@126.com; 16; 2900-2906; 38
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/417613]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Yu, Tao,Du, Yingxiang,Chen, Jiaquan,et al. Study on clarithromycin lactobionate based dual selector systems for the enantioseparation of basic drugs in capillary electrophoresis[J]. JOURNAL OF SEPARATION SCIENCE,2015.
APA	Yu, Tao.,Du, Yingxiang.,Chen, Jiaquan.,Xu, Guangfu.,Yang, Ke.,...&Zhang, Yanjie.(2015).Study on clarithromycin lactobionate based dual selector systems for the enantioseparation of basic drugs in capillary electrophoresis.JOURNAL OF SEPARATION SCIENCE.
MLA	Yu, Tao,et al."Study on clarithromycin lactobionate based dual selector systems for the enantioseparation of basic drugs in capillary electrophoresis".JOURNAL OF SEPARATION SCIENCE (2015).