Searching for more effective HCVNS3 protease inhibitors via modification   of corilagin

doi:10.1080/10020070512331343080

CORC > 北京大学 > 化学与分子工程学院

	Searching for more effective HCVNS3 protease inhibitors via modification of corilagin
	Wang, Y ; Yang, XS ; Li, ZQ ; Zhang, W ; Chen, LR ; Xu, XJ
刊名	progress in natural science
	2005
关键词	corilagin synthesis HCVNS3 serine protease molecular docking VIRUS NS3/4A PROTEASE HEPATITIS-C SERINE-PROTEASE
DOI	10.1080/10020070512331343080
英文摘要	Corilagin was seperated from extract of Phyllanthus urinaria L. and used as the precursor of inhibitors of hepatitis C virus (HCV) NS3 serine protease. Six derivatives were obtained through the chemical modification of corilagin and their structures were elucidated by the spectra analysis. Bioassay of these compounds showed that two of them had improved inhibitory efficiency than the precursor, with IC50 values of 2.28 mu mol/L and 1.52 mu mol/L, respectively. The binding mode of two active compounds with substrate binding site of HCV NS3 protease was also investigated by molecular docking method.; Materials Science, Multidisciplinary; Multidisciplinary Sciences; SCI(E); EI; 3; ARTICLE; 10; 896-901; 15
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/399581]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Wang, Y,Yang, XS,Li, ZQ,et al. Searching for more effective HCVNS3 protease inhibitors via modification of corilagin[J]. progress in natural science,2005.
APA	Wang, Y,Yang, XS,Li, ZQ,Zhang, W,Chen, LR,&Xu, XJ.(2005).Searching for more effective HCVNS3 protease inhibitors via modification of corilagin.progress in natural science.
MLA	Wang, Y,et al."Searching for more effective HCVNS3 protease inhibitors via modification of corilagin".progress in natural science (2005).