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	A Validated RP-HPLC Method for the Determination of Citrinin in Xuezhikang Capsule and other Monascus-Fermented Products
	Li Xue-Mei ; Shen Xing-Hai ; Xue Lan ; Duan Zhen-Wen ; Guo Shu-Ren
	2012
关键词	HPLC LC-MS/MS Citrinin Xuezhikang capsule Monascus
英文摘要	Citrinin is a toxic product usually produced during the Monascus fermentation. The presence of citrinin in xuezhikang capsule has been a concern due to its ingredient which is derived from monascus-fermented rice. A rapid and sensitive RP-HPLC method with fluorescence detection at lambda(ex) = 331 nm and lambda(em) = 500 nm for analysis of citrinin in Monascus-fermented products was developed to analyze citrinin in Monascus-fermented products. The chromatography was performed with mobile phase containing acidified water and acetonitrile. The calibration curve was linear (r = 0.9999) over a range of 0.0107-0.537 mu g/mL. The limit of detection (LOD) and the limit of quantitation (LOQ) were 0.187 ng/mL and 0.6 ng/mL respectively. The analysis of xuezhikang capsules using the developed method suggested that the product does not contain detectable citrinin and the result has been further confirmed using independent LC-MS/MS analysis. The proposed method has also been applied to analyze 11 samples of other Monascus-fermented products. The results suggested that there were no detectable citrinin in 4 of the 11 samples, however citrinin with the levels between 0.10-594 ng/kg has been detected in the other 7 samples. It indicates that the proposed method can also be applied to carry out the quantitative detection of citrinin for other Monascus-fermented products.; Chemistry, Multidisciplinary; SCI(E); 0; ARTICLE; 1; 260-266; 9
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/394068]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Li Xue-Mei,Shen Xing-Hai,Xue Lan,et al. A Validated RP-HPLC Method for the Determination of Citrinin in Xuezhikang Capsule and other Monascus-Fermented Products[J],2012.
APA	Li Xue-Mei,Shen Xing-Hai,Xue Lan,Duan Zhen-Wen,&Guo Shu-Ren.(2012).A Validated RP-HPLC Method for the Determination of Citrinin in Xuezhikang Capsule and other Monascus-Fermented Products..
MLA	Li Xue-Mei,et al."A Validated RP-HPLC Method for the Determination of Citrinin in Xuezhikang Capsule and other Monascus-Fermented Products".(2012).

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