Zinc Finger Antiviral Protein Inhibits Murine Gammaherpesvirus 68 M2   Expression and Regulates Viral Latency in Cultured Cells

doi:10.1128/JVI.01514-12

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	Zinc Finger Antiviral Protein Inhibits Murine Gammaherpesvirus 68 M2 Expression and Regulates Viral Latency in Cultured Cells
	Xuan, Yifang ; Liu, Ling ; Shen, Sheng ; Deng, Hongyu ; Gao, Guangxia
刊名	病毒学杂志
	2012
关键词	LYTIC REPLICATION MESSENGER-RNAS GENE RTA IDENTIFICATION ESTABLISHMENT DEGRADATION ACTIVATION INFECTION BINDS
DOI	10.1128/JVI.01514-12
英文摘要	Zinc finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses by binding to specific viral mRNAs and repressing mRNA expression. Here we report that ZAP inhibits expression of murine gammaherpesvirus 68 (MHV-68) M2, which plays important roles in establishment and maintenance of viral latency. Downregulation of endogenous ZAP in cells harboring latent MHV-68 promoted lytic replication of the virus. These results suggest that ZAP inhibits M2 expression and regulates the maintenance of MHV-68 latency.; Virology; SCI(E); 8; ARTICLE; 22; 12431-12434; 86
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/392560]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Xuan, Yifang,Liu, Ling,Shen, Sheng,et al. Zinc Finger Antiviral Protein Inhibits Murine Gammaherpesvirus 68 M2 Expression and Regulates Viral Latency in Cultured Cells[J]. 病毒学杂志,2012.
APA	Xuan, Yifang,Liu, Ling,Shen, Sheng,Deng, Hongyu,&Gao, Guangxia.(2012).Zinc Finger Antiviral Protein Inhibits Murine Gammaherpesvirus 68 M2 Expression and Regulates Viral Latency in Cultured Cells.病毒学杂志.
MLA	Xuan, Yifang,et al."Zinc Finger Antiviral Protein Inhibits Murine Gammaherpesvirus 68 M2 Expression and Regulates Viral Latency in Cultured Cells".病毒学杂志 (2012).