Synthesis of nitrated analogs of distamycin and their DNA cleaving and protecting activities under UV irradiation | |
Xiao, JH ; Yuan, G ; Huang, WQ ; Lum, JHK ; Lee, KLD ; Chan, ASC | |
刊名 | journal of the chinese chemical society
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2001 | |
关键词 | analogs of distamycin DNA cleaving and protecting activities MINOR-GROOVE DESIGN TARGETS |
英文摘要 | Two nitrated analogs of distamycin were synthesized by a novel haloform reaction and the DCC/HOBT coupling reaction in a convenient and effective way without amino group protection. Our results have demonstrated that these polyamides show DNA cleaving activity under long UV (LUV 365 nm) irradiation. Furthermore, it is an unexpected discovery that these analogs can prevent DNA damage under short LTV (SUV 302 nm).; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000172519800016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Multidisciplinary; SCI(E); 1; ARTICLE; 5; 929-932; 48 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/389102] ![]() |
专题 | 化学与分子工程学院 |
推荐引用方式 GB/T 7714 | Xiao, JH,Yuan, G,Huang, WQ,et al. Synthesis of nitrated analogs of distamycin and their DNA cleaving and protecting activities under UV irradiation[J]. journal of the chinese chemical society,2001. |
APA | Xiao, JH,Yuan, G,Huang, WQ,Lum, JHK,Lee, KLD,&Chan, ASC.(2001).Synthesis of nitrated analogs of distamycin and their DNA cleaving and protecting activities under UV irradiation.journal of the chinese chemical society. |
MLA | Xiao, JH,et al."Synthesis of nitrated analogs of distamycin and their DNA cleaving and protecting activities under UV irradiation".journal of the chinese chemical society (2001). |
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