Synthesis of nitrated analogs of distamycin and their DNA cleaving and   protecting activities under UV irradiation

CORC > 北京大学 > 化学与分子工程学院

	Synthesis of nitrated analogs of distamycin and their DNA cleaving and protecting activities under UV irradiation
	Xiao, JH ; Yuan, G ; Huang, WQ ; Lum, JHK ; Lee, KLD ; Chan, ASC
刊名	journal of the chinese chemical society
	2001
关键词	analogs of distamycin DNA cleaving and protecting activities MINOR-GROOVE DESIGN TARGETS
英文摘要	Two nitrated analogs of distamycin were synthesized by a novel haloform reaction and the DCC/HOBT coupling reaction in a convenient and effective way without amino group protection. Our results have demonstrated that these polyamides show DNA cleaving activity under long UV (LUV 365 nm) irradiation. Furthermore, it is an unexpected discovery that these analogs can prevent DNA damage under short LTV (SUV 302 nm).; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000172519800016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Multidisciplinary; SCI(E); 1; ARTICLE; 5; 929-932; 48
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/389102]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Xiao, JH,Yuan, G,Huang, WQ,et al. Synthesis of nitrated analogs of distamycin and their DNA cleaving and protecting activities under UV irradiation[J]. journal of the chinese chemical society,2001.
APA	Xiao, JH,Yuan, G,Huang, WQ,Lum, JHK,Lee, KLD,&Chan, ASC.(2001).Synthesis of nitrated analogs of distamycin and their DNA cleaving and protecting activities under UV irradiation.journal of the chinese chemical society.
MLA	Xiao, JH,et al."Synthesis of nitrated analogs of distamycin and their DNA cleaving and protecting activities under UV irradiation".journal of the chinese chemical society (2001).