Silver-catalysed direct amination of unactivated C-H bonds of   functionalized molecules

doi:10.1038/ncomms5707

CORC > 北京大学 > 化学与分子工程学院

	Silver-catalysed direct amination of unactivated C-H bonds of functionalized molecules
	Yang, Mingyu ; Su, Bo ; Wang, Yang ; Chen, Kang ; Jiang, Xingyu ; Zhang, Yun-Fei ; Zhang, Xi-Sha ; Chen, Guihua ; Cheng, Ye ; Cao, Zhichao ; Guo, Qing-Yun ; Wang, Lushun ; Shi, Zhang-Jie
刊名	nature communications
	2014
关键词	INTRAMOLECULAR FUNCTIONALIZATION HETEROCYCLE SYNTHESIS C(SP(2))-H BONDS ACTIVATION RADICALS AZETIDINES C(SP(3))-H AMIDATION CHEMISTRY POSITIONS
DOI	10.1038/ncomms5707
英文摘要	Carbon-nitrogen bond formation from inert C-H bonds is an ideal organic transformation and a highly desirable method for the synthesis of N-containing molecules due to its high efficiency and atom economy. In this report, we develop a general reaction to achieve an unprecedented selective intramolecular amination of unactivated C-H bond in the absence of complex directing groups. Functionalized heterocyclic products are built up from readily available linear amines through simple and reliable silver catalysis, representing a new silver-based C-H functionalization. This method displays preference for primary sp(3) C-H bonds and exhibits distinct chemo- and regioselectivity compared to existing methods of direct amination (Hofmann-Loffler-Freytag reaction and nitrene insertion). The study highlights the manipulation of unfunctionalized groups in organic molecules to furnish complex structural units in the natural and bioactive molecules.; Multidisciplinary Sciences; SCI(E); PubMed; 7; ARTICLE; zshi@pku.edu.cn; 4707; 5
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/342271]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Yang, Mingyu,Su, Bo,Wang, Yang,et al. Silver-catalysed direct amination of unactivated C-H bonds of functionalized molecules[J]. nature communications,2014.
APA	Yang, Mingyu.,Su, Bo.,Wang, Yang.,Chen, Kang.,Jiang, Xingyu.,...&Shi, Zhang-Jie.(2014).Silver-catalysed direct amination of unactivated C-H bonds of functionalized molecules.nature communications.
MLA	Yang, Mingyu,et al."Silver-catalysed direct amination of unactivated C-H bonds of functionalized molecules".nature communications (2014).