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	THE COMPLEXATION OF METALLOTHIONEIN WITH CADMIUM ION AND ITS CONFORMATIONAL STUDY
	CHU, DY ; LIN, Y ; LIU, RL ; RU, BG
	1991
关键词	CIRCULAR-DICHROISM PROTEIN BINDING LIVER RAT CD
英文摘要	The circular dichroic (CD) spectra of native mouse liver MT-2 (pH 6.10) and re-constituted MT (pH adjusted from 6.10 to 1.84, and then raised to 10.70) have been measured to determine if there are any conformational differences between them. The pH value corresponding to the complete dissociation of Cd2+ from rabbit MT-1 is 2.8. Compared with the data derived from a cadmium-selective electrode, the CD spectra of native rabbit liver MT-1 at different pH values (8.19, 4.44, 3.61, 2.94 and 1.92) demonstrate that the release of the metal ions with accompanied by a conformational change in the MT and that the metalthiolate bond is important in maintaining the secondary structure of MT. At pH 8.19 the addition of excess Cd2+ results in a significant change in the CD spectrum of rabbit MT-1, indicating that some metal clusters have been broken.; Chemistry, Analytical; Chemistry, Physical; SCI(E); 2
语种	英语
DOI标识	10.1016/0040-6031(91)80445-O
内容类型	其他
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/313556]
专题	化学与分子工程学院 生命科学学院
推荐引用方式 GB/T 7714	CHU, DY,LIN, Y,LIU, RL,et al. THE COMPLEXATION OF METALLOTHIONEIN WITH CADMIUM ION AND ITS CONFORMATIONAL STUDY. 1991-01-01.

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