Toward Functionalization of Thermoresponsive Poly(N-vinyl-2-pyrrolidone)

doi:10.1021/ma101636m

CORC > 北京大学 > 化学与分子工程学院

	Toward Functionalization of Thermoresponsive Poly(N-vinyl-2-pyrrolidone)
	Chen, Guang-Tao ; Wang, Chun-Hao ; Zhang, Jia-Guang ; Wang, Yang ; Zhang, Rui ; Du, Fu-Sheng ; Yan, Ning ; Kou, Yuan ; Li, Zi-Chen
刊名	macromolecules
	2010
关键词	OLIGO(ETHYLENE GLYCOL) METHACRYLATE TRANSFER RADICAL POLYMERIZATION LIVING CATIONIC-POLYMERIZATION CRITICAL SOLUTION TEMPERATURES AQUEOUS-SOLUTION PROPERTIES ACID-LABILE 2-(2-METHOXYETHOXY)ETHYL METHACRYLATE 2-HYDROXYETHYL METHACRYLATE DENDRONIZED POLYMERS PHASE-TRANSITIONS
DOI	10.1021/ma101636m
英文摘要	A series of new monomers with different substituents at the 3-position of N-vinyl-2-pyrrolidone (NVP) were synthesized. The substituents include simple alkyl (methyl, ethyl, propyl, and isopropyl), ether (methoxy ethyl and ethoxy ethyl), and functional groups (e.g., aldehyde, epoxy, and acetylene). These monomers were (co)polymerized radically to produce a family of (co)polymers based on poly(N-vinyl-2-pyrrolidone) (PVP), and the copolymer compositions could be controlled through varying comonomer feed ratio. When the monomers are substituted with ethyl-, methyl-, or ether-containing alkyl chains, their homopolymers are soluble in cold water but display sensitive and reversible phase transition upon heating to a cloud point temperature (CP). Control over CP of homopolymers was achieved by changing the hydrophilicity of the substituents. CP could also be tuned by copolymerization of different monomers or adding NaCl to the polymer aqueous solution. The mechanism of the thermoresponsive properties was studied by temperature-dependent H-1 NMR and microcalorimetry. The results confirmed that the phase transitions of (co)polymers bearing ether substituents were less cooperative with lower phase transition enthalpy and less dehydration even at temperatures well above the CP, and the transition is predominately liquid to liquid. In addition, aldehyde, epoxy, and acetylene groups were introduced to the (co)polymer chains as reactive groups; model reactions of these groups with other molecules were very efficient and simple. Thus, these polymers can subsequently be modified to impart additional functionality to be used as thermoresponsive polymers for bioconjugation. Finally, these polymers are demonstrated to be at least as biocompatible as PVP.; Polymer Science; SCI(E); 21; ARTICLE; 23; 9972-9981; 43
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/313176]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Chen, Guang-Tao,Wang, Chun-Hao,Zhang, Jia-Guang,et al. Toward Functionalization of Thermoresponsive Poly(N-vinyl-2-pyrrolidone)[J]. macromolecules,2010.
APA	Chen, Guang-Tao.,Wang, Chun-Hao.,Zhang, Jia-Guang.,Wang, Yang.,Zhang, Rui.,...&Li, Zi-Chen.(2010).Toward Functionalization of Thermoresponsive Poly(N-vinyl-2-pyrrolidone).macromolecules.
MLA	Chen, Guang-Tao,et al."Toward Functionalization of Thermoresponsive Poly(N-vinyl-2-pyrrolidone)".macromolecules (2010).