The heme oxygenase-1 inhibitor ZnPPIX induces non-canonical, Beclin   1-independent, autophagy through p38 MAPK pathway

doi:10.1093/abbs/gms064

CORC > 北京大学 > 化学与分子工程学院

	The heme oxygenase-1 inhibitor ZnPPIX induces non-canonical, Beclin 1-independent, autophagy through p38 MAPK pathway
	Zhou, Cuihong ; Zhou, Jun ; Sheng, Fugeng ; Zhu, Haichuan ; Deng, Xiaoyan ; Xia, Bin ; Lin, Jian
刊名	acta biochimica et biophysica sinica
	2012
关键词	ZnPPIX autophagy Beclin1-independent autophagy p38 ZINC PROTOPORPHYRIN CELL-DEATH CANCER STRESS TUMOR
DOI	10.1093/abbs/gms064
英文摘要	Zinc protoporphyrin IX (ZnPPIX), a heme oxygenase-1 enzyme inhibitor, has been reported to induce apoptosis and to have antitumor properties. Here, we report that ZnPPIX triggers autophagy and causes defective autophagy flux in HeLa cells. Autophagosome formation was independent of Beclin 1, indicating non-canonical autophagy activity in ZnPPIX-treated cells. Furthermore, western blot results indicated that p38 MAPK (mitogen-activated protein kinase) was phosphorylated in treated cells. Consistently, SB203580 (a p38 inhibitor) obviously inhibited the accumulation of autophagosomes. Our results indicated that p38 MAPK may be a key regulator for non-canonical Beclin1-independent autophagy.; Biochemistry & Molecular Biology; Biophysics; SCI(E); 中国科技核心期刊(ISTIC); 5; ARTICLE; 10; 815-822; 44
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/313082]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhou, Cuihong,Zhou, Jun,Sheng, Fugeng,et al. The heme oxygenase-1 inhibitor ZnPPIX induces non-canonical, Beclin 1-independent, autophagy through p38 MAPK pathway[J]. acta biochimica et biophysica sinica,2012.
APA	Zhou, Cuihong.,Zhou, Jun.,Sheng, Fugeng.,Zhu, Haichuan.,Deng, Xiaoyan.,...&Lin, Jian.(2012).The heme oxygenase-1 inhibitor ZnPPIX induces non-canonical, Beclin 1-independent, autophagy through p38 MAPK pathway.acta biochimica et biophysica sinica.
MLA	Zhou, Cuihong,et al."The heme oxygenase-1 inhibitor ZnPPIX induces non-canonical, Beclin 1-independent, autophagy through p38 MAPK pathway".acta biochimica et biophysica sinica (2012).