Tumor-inhibitory effect and immunomodulatory activity of fullerol   C-60(OH)(x)

doi:10.1002/smll.200701219

CORC > 北京大学 > 化学与分子工程学院

	Tumor-inhibitory effect and immunomodulatory activity of fullerol C-60(OH)(x)
	Zhu, Jiadan ; Ji, Zhiqiang ; Wang, Jing ; Sun, Ronghua ; Zhang, Xiang ; Gao, Yang ; Sun, Hongfang ; Liu, Yuanfang ; Wang, Zheng ; Li, Aidong ; Ma, Jie ; Wang, Tiancheng ; Jia, Guang ; Gu, Yiqun
刊名	small
	2008
关键词	antitumor agents fullerol immunology macrophages toxicology MURINE PERITONEAL-MACROPHAGES NITRIC-OXIDE SYNTHASE IN-VITRO ANTITUMOR-ACTIVITY BIOLOGICAL APPLICATIONS ALVEOLAR MACROPHAGES C-60 DERIVATIVES TOXICITY CELLS
DOI	10.1002/smll.200701219
英文摘要	The tumor-inhibitory effect of C-60(OH)(x) was tested on the murine H22 hepatocarcinoma model. Doses of 0.2 and 1.0 mg kg(-1) body weight both showed significant antitumor activity with tumor inhibition rates of 31.9 and 38.4%, respectively, when mice were treated for 17 consecutive days. The damnification of liver was prominently reduced. Furthermore, histological examination indicated that an envelope of fibroblasts and lymphocytes was formed surrounding tumor tissues in the C-60(OH)(x)-treated group, which inhibited the infiltration of tumor to the neighboring normal skeleton muscle tissues. To understand the antitumor mechanism, the immunomodulatory activity of C-60(OH)(x) was investigated. The results indicate that C-60(OH)(x) enhances the phagocytosis of peritoneal macrophages and elevates the activity of arginase and acid phosphatase in vivo. The tumor necrosis factor alpha production of C-60(OH)(x)-treated macrophages also increases in vitro. These results suggest that C-60(OH)(x) can enhance the innate immunity of tumor-bearing mice, and therefore inhibits growth of the tumor.; Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter; SCI(E); EI; PubMed; 40; ARTICLE; 8; 1168-1175; 4
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/312620]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhu, Jiadan,Ji, Zhiqiang,Wang, Jing,et al. Tumor-inhibitory effect and immunomodulatory activity of fullerol C-60(OH)(x)[J]. small,2008.
APA	Zhu, Jiadan.,Ji, Zhiqiang.,Wang, Jing.,Sun, Ronghua.,Zhang, Xiang.,...&Gu, Yiqun.(2008).Tumor-inhibitory effect and immunomodulatory activity of fullerol C-60(OH)(x).small.
MLA	Zhu, Jiadan,et al."Tumor-inhibitory effect and immunomodulatory activity of fullerol C-60(OH)(x)".small (2008).