Cytotoxic steroids from Monascus purpureus-fermented rice

doi:10.1016/j.steroids.2011.05.008

CORC > 北京大学 > 化学与分子工程学院

	Cytotoxic steroids from Monascus purpureus-fermented rice
	Shang, Xiao-Ya ; Li, Jin-Jie ; Liu, Ming-Tao ; Li, Shuai ; Liu, Ying ; Wang, Ye-Feng ; Huang, Xiao ; Jin, Zong-Lian
刊名	steroids
	2011
关键词	Monascus purpureus Absolute configuration X-ray single crystal diffraction Cytotoxicity AZAPHILONES
DOI	10.1016/j.steroids.2011.05.008
英文摘要	Bioassay-guided fractionation of an EtOH extract of Monascus purpureus-fermented rice led to the isolation of two new steroids (22S, 23R, 24S)-20 beta,23 alpha,25 alpha-trihydroxy-16,22-epoxy-4,6,8(14)-trienergosta-3-one (1), the first example of a steroid possessing both a conjugated triene ketone system and a fused 4H-furan ring side chain within one molecule, and (22E, 24R)-3 beta,5 alpha-dihydroxyergosta-23-methyl-7,22-dien-6-one (2), as well as two known compounds (22E, 24R)-3 beta,5 alpha-dihydroxyergosta-7,22-dien-6-one (3) and (22E, 24R)-6 beta-methoxy-ergosta-7,22-diene-3 beta,5 alpha-diol (4). Their structures were assigned by detailed interpretation of HRESIMS, 1D and 2D NMR spectroscopic data. The absolute stereochemistry of 1 was determined by single-crystal X-ray crystallography while the absolute stereochemistry of 2 was established by CD. Compounds 1-4 showed cytotoxic activity against the lung adenocarcinoma (A549) with IC(50) values of 0.08, 0.94, 12.6 and 13.5 mu M, respectively. In addition, compounds 1 and 2 exhibited moderate activities against human ovarian cancer (A2780), with IC(50) values of 2.8 and 5.1 mu M. (C) 2011 Elsevier Inc. All rights reserved.; Biochemistry & Molecular Biology; Endocrinology & Metabolism; SCI(E); 8; ARTICLE; 10-11; 1185-1189; 76
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/257444]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Shang, Xiao-Ya,Li, Jin-Jie,Liu, Ming-Tao,et al. Cytotoxic steroids from Monascus purpureus-fermented rice[J]. steroids,2011.
APA	Shang, Xiao-Ya.,Li, Jin-Jie.,Liu, Ming-Tao.,Li, Shuai.,Liu, Ying.,...&Jin, Zong-Lian.(2011).Cytotoxic steroids from Monascus purpureus-fermented rice.steroids.
MLA	Shang, Xiao-Ya,et al."Cytotoxic steroids from Monascus purpureus-fermented rice".steroids (2011).