The interaction of Co2+ ions and sodium deoxycholate micelles

doi:10.1016/S0022-2860(03)00297-7

CORC > 北京大学 > 化学与分子工程学院

	The interaction of Co2+ ions and sodium deoxycholate micelles
	Sun, Y ; Yang, ZL ; Zhang, L ; Zhou, NF ; Weng, SF ; Wu, JG
刊名	分子结构杂志
	2003
关键词	cobalt deoxycholate sodium deoxycholate steroid micelle gel FT-IR spectra BILE-SALT MICELLES TRANSITION-METAL IONS CALCIUM-IONS BINDING CHOLATE GLYCOCHOLATE TAUROCHOLATE MONOHYDRATE AGGREGATION COMPLEXES
DOI	10.1016/S0022-2860(03)00297-7
英文摘要	To mimic the interaction between divalent metal ions and bile slats in vivo, two groups of coordination complex compounds, crystalline and gel-like, were synthesized in vitro by mixing the aqueous solutions Of CoCl2 with sodium deoxycholate (NaDC) at various concentrations. Structures and compositions of the compounds were investigated using FT-IR, EXAFS, XRD as well as elemental and ICP analysis, respectively. Then the interaction of Co2+ with deoxycholate in solution was observed by laser light scattering (LLS), Transmission electronic microscope techniques and ICP analysis. Conclusions are (1) the crystalline complexes, Co (DC)(2).3H(2)O were obtained by reaction of Co2+ with mono-molecules of NaDC, and the gel-like complexes, NanCom(DC)(n+2m) formed by reaction of Co2+ with NaDC micelles. The gel-like complexes exhibit the non-stoichiometric character; (2) the coordination structures of carboxyl groups with Co2+ were different between the crystalline and gel-like complexes. In Co(DC)(2).3H(2)O complex, the carboxyl groups of deoxycholate coordinated with Co2+ in chelating and pseudo-chelating modes, but that in bridge mode in the case of NanCom(DC)(n+2m) complexes. The non-stoichiometric complexes of NanCom(DC)(n+2m) are formed with a macromolecular structure through the Co2+ bridges; (3) NaDC can increase the solubility of Co(DC)(2).3H(2)O in aqueous solution, and larger micelles (30-80 nm diameter) formed in the supernate. It is a mixed micelle formed by Co2+ ions bridges connecting with NaDC simple micelles. So these micelles are a new kind of micelle, containing two kinds of metal ions; (4) these results are in agreement with those formed under physiological conditions in that the different states such as gel, precipitate, micelles of various structures are present in bile of gallbladder. An ideal model of the interaction between Co2+ and bile salts in vivo has been proposed. (C) 2003 Elsevier Science B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000184211900013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Physical; SCI(E); 13; ARTICLE; 2; 321-330; 655
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/256446]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Sun, Y,Yang, ZL,Zhang, L,et al. The interaction of Co2+ ions and sodium deoxycholate micelles[J]. 分子结构杂志,2003.
APA	Sun, Y,Yang, ZL,Zhang, L,Zhou, NF,Weng, SF,&Wu, JG.(2003).The interaction of Co2+ ions and sodium deoxycholate micelles.分子结构杂志.
MLA	Sun, Y,et al."The interaction of Co2+ ions and sodium deoxycholate micelles".分子结构杂志 (2003).