Facile synthesis of C-2-symmetric tridentate bis(thiazoline) and   bis(oxazoline) ligands and their application in the enantioselective   Henry reaction

doi:10.1016/j.tetasy.2004.09.011

CORC > 北京大学 > 化学与分子工程学院

	Facile synthesis of C-2-symmetric tridentate bis(thiazoline) and bis(oxazoline) ligands and their application in the enantioselective Henry reaction
	Lu, SF ; Du, DM ; Zhang, SW ; Xu, JX
刊名	tetrahedron asymmetry
	2004
关键词	ASYMMETRIC NITROALDOL REACTION NOZAKI-HIYAMA ALLYLATION BISOXAZOLINE LIGANDS BINOL COMPLEXES BIS(OXAZOLINYL)PYRIDINE PYBOX CATALYTIC CYCLOPROPANATION TRANSFER HYDROGENATION ZINC(II) PERCHLORATE ADDITION-REACTIONS AMINO-ALCOHOLS
DOI	10.1016/j.tetasy.2004.09.011
英文摘要	A series of novel C-2-symmetric bis(thiazoline) ligands with a diphenylamine backbone as a linkage between two thiazoline rings were synthesized by the use of the simple reagent phosphorus pentasulfide. Their application in the catalytic asymmetric Henry reaction of alpha-keto esters was investigated with comparison to the corresponding bis(oxazoline) ligands. Cu(II)-bis(oxazoline) complexes furnished moderate enantioselectivities (up to 60% ee), while Cu(II)-bis(thiazoline) complexes gave higher enantioselectivities (up to 70% ee) with neat nitromethane. The enantioselectivity was improved when a halogenated solvent, such as CH2Cl2 was used (up to 82% ee), but the yield obtained lower than that in neat reactions. (C) 2004 Elsevier Ltd. All rights reserved.; Chemistry, Inorganic & Nuclear; Chemistry, Organic; Chemistry, Physical; SCI(E); 128; ARTICLE; 21; 3433-3441; 15
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/254767]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Lu, SF,Du, DM,Zhang, SW,et al. Facile synthesis of C-2-symmetric tridentate bis(thiazoline) and bis(oxazoline) ligands and their application in the enantioselective Henry reaction[J]. tetrahedron asymmetry,2004.
APA	Lu, SF,Du, DM,Zhang, SW,&Xu, JX.(2004).Facile synthesis of C-2-symmetric tridentate bis(thiazoline) and bis(oxazoline) ligands and their application in the enantioselective Henry reaction.tetrahedron asymmetry.
MLA	Lu, SF,et al."Facile synthesis of C-2-symmetric tridentate bis(thiazoline) and bis(oxazoline) ligands and their application in the enantioselective Henry reaction".tetrahedron asymmetry (2004).