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	A surface plasmon resonance imaging interferometry for protein micro-array detection
	Yu, XL ; Wang, DX ; Wei, X ; Ding, X ; Liao, W ; Zhao, XS
	2005
关键词	surface plasmon resonance micro-array phase detection interference of polarized light spatial phase modulation MICROARRAYS PROTEOMICS PARALLEL SENSOR
英文摘要	A kind of common-optical-path SPR imaging interferometry for micro-array detection is presented. It is a combination of SPR and spatial phase modulation measurement. In this method, the SPR sensing chip surface is illuminated with collimated parallel light beam, and a Wollaston prism is introduced into the reflected light path to produce the interference of polarized light reflected from SPR sensing chip. The p-polarization and s-polarization lights serve as measurement and reference beam, respectively. The information of biochemical reactions can be obtained by extracting the phase change from the SPR interference patterns. As a common-optical-path interferometry, it can reduce disturbances from the ambient conditions. Furthermore, this method is competent for real-time array detection. Various solution concentration and antigen-antibody interaction have been measured with this method. The experiment results indicate that the method can detect micro-array chips in real time. It opens up a new avenue for high-throughput SPR micro-array phase detection, which will benefit the drug discovery and proteomics study. (c) 2005 Elsevier B.V. All rights reserved.; Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation; SCI(E); EI; CPCI-S(ISTP); 24
语种	英语
DOI标识	10.1016/j.snb.2004.12.089
内容类型	其他
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/253230]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Yu, XL,Wang, DX,Wei, X,et al. A surface plasmon resonance imaging interferometry for protein micro-array detection. 2005-01-01.

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