Radiation synthesis of poly[(dimethylaminoethylmethacrylate)-co-(diallyl   dimethyl ammonium chloride)] hydrogels and its application as a carrier   for notoginsenoside delivery

doi:10.1016/j.eurpolymj.2006.08.008

CORC > 北京大学 > 化学与分子工程学院

	Radiation synthesis of poly[(dimethylaminoethylmethacrylate)-co-(diallyl dimethyl ammonium chloride)] hydrogels and its application as a carrier for notoginsenoside delivery
	Zhang, Yalong ; Xu, Ling ; Yi, Min ; Zhai, Maolin ; Wang, Jianrui ; Ha, Hongfei
刊名	欧洲聚合物杂志
	2006
关键词	poly(DMAEMA-co-DADMAC) hydrogels pH/temperature stimuli-response controlled release notoginsenoside Chinese herb extract GENE-TRANSFER AGENTS 2-(DIMETHYLAMINO)ETHYL METHACRYLATE DIALLYLDIMETHYLAMMONIUM CHLORIDE AMINE METHACRYLATE UV-IRRADIATION COPOLYMERS TEMPERATURE RESPONSIVENESS POLYMERS RELEASE
DOI	10.1016/j.eurpolymj.2006.08.008
英文摘要	Novel pH/temperature sensitive hydrogel was synthesized by radiation induced copolymerization and cross-linking of dimethylaminoethyl methacrylate (DMAEMA) and diallyldimethyl ammonium chloride (DADMAC). Reactivity ratio of DADMAC (r(1)) and DMAEMA (r(2)) was determined as 1.02 and 0.98, which means that poly(DMAEMA-co-DADMAC) is an azeotropic copolymer. Content of DADMAC, i.e., charge density of the hydrogel was found to influence their properties significantly. Compared with polyDMAEMA hydrogel, poly(DMAEMA-co-DADMAC) showed enhanced equilibrium degree of swelling (EDS). Low critical solution temperature (LCST) of the hydrogel increased with the charged density. Content of DADMAC had no effect on the pH dependence of the final gel. Aiming at its application as a carrier for Chinese herb extract delivery system, the embedment and pH/temperature dependence of controlled release were investigated using notoginsenoside as a model drug. The maximum embedment amount of notoginsenoside was obtained in a gel containing 3 mol.% DADMAC. The temperature dependence and pH dependence of notoginsenoside release followed the same trend as that of EDS, for instance, higher ratio of notoginsenoside release occurred at 25 degrees C and pH 1.7, at which higher EDS was obtained. By these means, the release of notoginsenoside can be controlled by adjusting the pH, ionic strength, temperature of solution as well as the composition and structure of the gel. (c) 2006 Elsevier Ltd. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000242051000007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Polymer Science; SCI(E); EI; 40; ARTICLE; 11; 2959-2967; 42
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/251318]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhang, Yalong,Xu, Ling,Yi, Min,et al. Radiation synthesis of poly[(dimethylaminoethylmethacrylate)-co-(diallyl dimethyl ammonium chloride)] hydrogels and its application as a carrier for notoginsenoside delivery[J]. 欧洲聚合物杂志,2006.
APA	Zhang, Yalong,Xu, Ling,Yi, Min,Zhai, Maolin,Wang, Jianrui,&Ha, Hongfei.(2006).Radiation synthesis of poly[(dimethylaminoethylmethacrylate)-co-(diallyl dimethyl ammonium chloride)] hydrogels and its application as a carrier for notoginsenoside delivery.欧洲聚合物杂志.
MLA	Zhang, Yalong,et al."Radiation synthesis of poly[(dimethylaminoethylmethacrylate)-co-(diallyl dimethyl ammonium chloride)] hydrogels and its application as a carrier for notoginsenoside delivery".欧洲聚合物杂志 (2006).