Acute toxicological impact of nano- and submicro-scaled zinc oxide   powder on healthy adult mice

doi:10.1007/s11051-007-9245-3

CORC > 北京大学 > 化学与分子工程学院

	Acute toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice
	Wang, Bing ; Feng, Weiyue ; Wang, Meng ; Wang, Tiancheng ; Gu, Yiqun ; Zhu, Motao ; Ouyang, Hong ; Shi, Junwen ; Zhang, Fang ; Zhao, Yuliang ; Chai, Zhifang ; Wang, Haifang ; Wang, Jing
刊名	journal of nanoparticle research
	2008
关键词	acute oral toxicity nano-meter zinc oxide powder submicro-meter zinc oxide powder mice toxicology health effects medicine PARTICULATE AIR-POLLUTION INDUCED HEMOLYTIC-ANEMIA ULTRAFINE PARTICLES SURFACE-AREA IN-VIVO TOXICITY INSTILLATION FINE DEFICIENCY NANOSCALE
DOI	10.1007/s11051-007-9245-3
英文摘要	In this work, the acute oral toxicity of 20- and 120-nm ZnO powder at doses of 1-, 2-, 3-, 4-, 5-g/kg body weight was evaluated referred to the OECD guidelines for testing of chemicals. As the results, both 20- and 120-nm ZnO belong to non-toxic chemicals according to the Globally Harmonized Classification System (GHS) for the classification of chemicals. The distribution determination showed that Zn was mainly retained in the bone, kidney and pancreas after 20- and 120-nm ZnO administration. However, the results of blood measurement suggest that the increase in blood viscosity could be induced by low and median dose of 20-nm ZnO but high dose of 120-nm ZnO. The pathological examination showed that the 120-nm ZnO treated mice had dose-effect pathological damages in stomach, liver, heart and spleen, whereas, 20-nm ZnO displayed negative dose-effect damages in liver, spleen and pancreas. Therefore, we conclude that the liver, spleen, heart, pancreas and bone are the target organs for 20- and 120-nm ZnO oral exposure. More attention should be paid on the potential toxicity induced by low dose of 20-nm ZnO oral exposure.; Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; SCI(E); EI; 94; ARTICLE; 2; 263-276; 10
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/249556]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Wang, Bing,Feng, Weiyue,Wang, Meng,et al. Acute toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice[J]. journal of nanoparticle research,2008.
APA	Wang, Bing.,Feng, Weiyue.,Wang, Meng.,Wang, Tiancheng.,Gu, Yiqun.,...&Wang, Jing.(2008).Acute toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice.journal of nanoparticle research.
MLA	Wang, Bing,et al."Acute toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice".journal of nanoparticle research (2008).