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	Histopathology mapping of biochemical changes in myocardial infarction by Fourier transform infrared spectral imaging
	Yang, Tian T. ; Weng, Shi F. ; Zheng, Na ; Pan, Qing H. ; Cao, Hong L. ; Liu, Liang ; Zhang, Hai D. ; Mu, Da W.
	2011
关键词	Fourier transform infrared (FTIR) spectroscopy Imaging Histopathology Myocardial infarction FT-IR SPECTROSCOPY MICROSCOPY CELLS
DOI	10.1016/j.forsciint.2010.12.005
英文摘要	Fourier transform infrared (FTIR) imaging and microspectroscopy have been extensively applied in the identification and investigation of both healthy and diseased tissues. FTIR imaging can be used to determine the biodistribution of several molecules of interest (carbohydrates, lipids, proteins) for tissue analysis, without the need for prior staining of these tissues. Molecular structure data, such as protein secondary structure and collagen triple helix exhibits, can also be obtained from the same analysis. Thus, several histopathological lesions, for example myocardial infarction, can be identified from FTIR-analyzed tissue images, the latter which can allow for more accurate discrimination between healthy tissues and pathological lesions. Accordingly, we propose FTIR imaging as a new tool integrating both molecular and histopathological assessment to investigate the degree of pathological changes in tissues. In this study, myocardial infarction is presented as an illustrative example of the wide potential of FTIR imaging for biomedical applications. (C) 2010 Elsevier Ireland Ltd. All rights reserved.; Medicine, Legal; SCI(E); 10; ARTICLE; 1-3; E34-E39; 207
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/240049]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Yang, Tian T.,Weng, Shi F.,Zheng, Na,et al. Histopathology mapping of biochemical changes in myocardial infarction by Fourier transform infrared spectral imaging[J],2011.
APA	Yang, Tian T..,Weng, Shi F..,Zheng, Na.,Pan, Qing H..,Cao, Hong L..,...&Mu, Da W..(2011).Histopathology mapping of biochemical changes in myocardial infarction by Fourier transform infrared spectral imaging..
MLA	Yang, Tian T.,et al."Histopathology mapping of biochemical changes in myocardial infarction by Fourier transform infrared spectral imaging".(2011).

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