Photon-Manipulated Drug Release from a Mesoporous Nanocontainer   Controlled by Azobenzene-Modified Nucleic Acid

doi:10.1021/nn3018365

CORC > 北京大学 > 化学与分子工程学院

	Photon-Manipulated Drug Release from a Mesoporous Nanocontainer Controlled by Azobenzene-Modified Nucleic Acid
	Yuan, Quan ; Zhang, Yunfei ; Chen, Tao ; Lu, Danqing ; Zhao, Zilong ; Zhang, Xiaobing ; Li, Zhenxing ; Yan, Chun-Hua ; Tan, Weihong
刊名	acs nano
	2012
关键词	azobenzene photoregulation mesoporous silica nucleic acids drug delivery SILICA NANOSPHERE DNA NANOMACHINES GUEST MOLECULES DELIVERY MACHINES SYSTEM
DOI	10.1021/nn3018365
英文摘要	Herein a photon-manipulated mesoporous release system was constructed based on azobenzene-modified nucleic acids. In this system, the azobenzene-incorporated DNA double strands were immobilized at the pore mouth of mesoporous silica nanoparticles. The photoisomerization of azobenzene induced dehybridization/hybridization switch of complementary DNA, causing uncapping/capping of pore gates of mesoporous silica. This nanoplatform permits holding of guest molecules within the nanopores under visible light but releases them when light wavelength turns to the UV range. These DNA/mesoporous silica hybrid nanostructures were exploited as carriers for the cancer cell chemotherapy drug doxorubicin (DOX) due to its stimuli-responsive property as well as good biocompatibility via MTT assay. It is found that the drug release behavior is light-wavelength-sensitive. Switching of the light from visible to the UV range uncapped the pores, causing the release of DOX from the mesoporous silica nanospheres and an obvious cytotoxic effect on cancer cells. We envision that this photocontrolled drug release system could find potential applications in cancer therapy.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000306673800066&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; SCI(E); EI; 105; ARTICLE; 7; 6337-6344; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/232392]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Yuan, Quan,Zhang, Yunfei,Chen, Tao,et al. Photon-Manipulated Drug Release from a Mesoporous Nanocontainer Controlled by Azobenzene-Modified Nucleic Acid[J]. acs nano,2012.
APA	Yuan, Quan.,Zhang, Yunfei.,Chen, Tao.,Lu, Danqing.,Zhao, Zilong.,...&Tan, Weihong.(2012).Photon-Manipulated Drug Release from a Mesoporous Nanocontainer Controlled by Azobenzene-Modified Nucleic Acid.acs nano.
MLA	Yuan, Quan,et al."Photon-Manipulated Drug Release from a Mesoporous Nanocontainer Controlled by Azobenzene-Modified Nucleic Acid".acs nano (2012).