Modifying mesoporous silica nanoparticles to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy | |
Wang, Wenjing ; Fang, Chenjie ; Wang, Xiaozhu ; Chen, Yuxi ; Wang, Yaonan ; Feng, Wei ; Yan, Chunhua ; Zhao, Ming ; Peng, Shiqi | |
刊名 | nanoscale
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2013 | |
关键词 | SOL-GEL MATERIALS CONTROLLED-RELEASE GENE DELIVERY CANCER CELLS STABILIZATION LIPOSOMES COPOLYMER THERAPY FOLATE |
DOI | 10.1039/c3nr00227f |
英文摘要 | Mesoporous silica nanoparticles with amino and thiol groups (MSNSN) were prepared and covalently modified with methotrexate and 6-mercaptopurine to form 6-MP-MSNSN-MTX. In the presence of DTT, 6-MP-MSNSN-MTX gradually releases 6-MP. In rat plasma, 6-MP-MSNSN-MTX effectively inhibits the metabolic deactivation of 6-MP and MTX. 6-MP-MSNSN-MTX could be an agent for long-acting chemotherapy.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000321014900005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; SCI(E); EI; 6; ARTICLE; 14; 6249-6253; 5 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/228102] ![]() |
专题 | 化学与分子工程学院 |
推荐引用方式 GB/T 7714 | Wang, Wenjing,Fang, Chenjie,Wang, Xiaozhu,et al. Modifying mesoporous silica nanoparticles to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy[J]. nanoscale,2013. |
APA | Wang, Wenjing.,Fang, Chenjie.,Wang, Xiaozhu.,Chen, Yuxi.,Wang, Yaonan.,...&Peng, Shiqi.(2013).Modifying mesoporous silica nanoparticles to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy.nanoscale. |
MLA | Wang, Wenjing,et al."Modifying mesoporous silica nanoparticles to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy".nanoscale (2013). |
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