Modifying mesoporous silica nanoparticles to avoid the metabolic   deactivation of 6-mercaptopurine and methotrexate in combinatorial   chemotherapy

doi:10.1039/c3nr00227f

CORC > 北京大学 > 化学与分子工程学院

	Modifying mesoporous silica nanoparticles to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy
	Wang, Wenjing ; Fang, Chenjie ; Wang, Xiaozhu ; Chen, Yuxi ; Wang, Yaonan ; Feng, Wei ; Yan, Chunhua ; Zhao, Ming ; Peng, Shiqi
刊名	nanoscale
	2013
关键词	SOL-GEL MATERIALS CONTROLLED-RELEASE GENE DELIVERY CANCER CELLS STABILIZATION LIPOSOMES COPOLYMER THERAPY FOLATE
DOI	10.1039/c3nr00227f
英文摘要	Mesoporous silica nanoparticles with amino and thiol groups (MSNSN) were prepared and covalently modified with methotrexate and 6-mercaptopurine to form 6-MP-MSNSN-MTX. In the presence of DTT, 6-MP-MSNSN-MTX gradually releases 6-MP. In rat plasma, 6-MP-MSNSN-MTX effectively inhibits the metabolic deactivation of 6-MP and MTX. 6-MP-MSNSN-MTX could be an agent for long-acting chemotherapy.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000321014900005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; SCI(E); EI; 6; ARTICLE; 14; 6249-6253; 5
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/228102]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Wang, Wenjing,Fang, Chenjie,Wang, Xiaozhu,et al. Modifying mesoporous silica nanoparticles to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy[J]. nanoscale,2013.
APA	Wang, Wenjing.,Fang, Chenjie.,Wang, Xiaozhu.,Chen, Yuxi.,Wang, Yaonan.,...&Peng, Shiqi.(2013).Modifying mesoporous silica nanoparticles to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy.nanoscale.
MLA	Wang, Wenjing,et al."Modifying mesoporous silica nanoparticles to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy".nanoscale (2013).