Evaluation of aminoquinoline-imprinted polymers and the recognition   mechanism

doi:10.1002/app.39094

CORC > 北京大学 > 化学与分子工程学院

	Evaluation of aminoquinoline-imprinted polymers and the recognition mechanism
	Zhang, Tieli ; Liu, Feng ; Li, Kean
刊名	应用聚合物科学杂志
	2013
关键词	molecular recognition properties and characterization copolymers cross-linking radical polymerization SELECTIVE DETERMINATION ACID MORPHOLOGY BINDING
DOI	10.1002/app.39094
英文摘要	Three molecularly imprinted polymers P(2-AQ), P(3-AQ), and P(8-AQ) based on methacrylic acid (MAA)-ethylene glycol dimethacrylate were prepared using isomers 2-aminoquinoline (2-AQ), 3-aminoquinoline (3-AQ), and 8-aminoquinoline (8-AQ) as template, respectively, by non-covalent bulk polymerization technique. Neither P(3-AQ) nor P(8-AQ) exhibited imprinting effect for 3-AQ or 8-AQ, whereas P(2-AQ) showed significant imprinting effect for 2-AQ. This indicates that the position of amino group on the quinoline ring has crucial influence on imprinting effect. The recognition mechanism of P(2-AQ) was investigated extensively by such methods as selective experiments, comparative study with 2-aminopyridine-imprinted polymer, and effect of different kinds of mobile phases. It is confirmed that there are complementary cavities in P(2-AQ) both in size and in the arrangement of functional groups to 2-AQ, and MAA binds 2-AQ via cyclic hydrogen bond. Furthermore, the influence of synthetic conditions on 2-AQ-imprinted polymers was explored. We found 2-AQ-imprinted polymer synthesized in acetonitrile porogen showed higher imprinting effect for 2-AQ than that prepared in chloroform. It is deduced that the morphology of the former might be more favorable to 2-AQ binding, which is also supported indirectly by the fluorimetric experiments estimating the interaction of 2-AQ with MAA in these two porogens. Additionally, 2-AQ-imprinted polymers prepared using two different amounts of acetonitrile exhibited very different imprinting effects, which suggested that porogen amount used in the imprinting process exerted significant influence. In addition to the in-depth elucidation of the recognition mechanism of 2-AQ-imprinted polymer, this article provides the basis for the separation and enrichment of bioactive 2-AQ. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000320615200044&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Polymer Science; SCI(E); EI; 1; ARTICLE; 6; 3447-3453; 129
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/220496]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhang, Tieli,Liu, Feng,Li, Kean. Evaluation of aminoquinoline-imprinted polymers and the recognition mechanism[J]. 应用聚合物科学杂志,2013.
APA	Zhang, Tieli,Liu, Feng,&Li, Kean.(2013).Evaluation of aminoquinoline-imprinted polymers and the recognition mechanism.应用聚合物科学杂志.
MLA	Zhang, Tieli,et al."Evaluation of aminoquinoline-imprinted polymers and the recognition mechanism".应用聚合物科学杂志 (2013).