Network pharmacology study on the mechanism of traditional Chinese   medicine for upper respiratory tract infection

doi:10.1039/c4mb00164h

CORC > 北京大学 > 化学与分子工程学院

	Network pharmacology study on the mechanism of traditional Chinese medicine for upper respiratory tract infection
	Zhang, Xinzhuang ; Gu, Jiangyong ; Cao, Liang ; Li, Na ; Ma, Yiming ; Su, Zhenzhen ; Ding, Gang ; Chen, Lirong ; Xu, Xiaojie ; Xiao, Wei
刊名	分子生物系统
	2014
关键词	DRUG DISCOVERY REDUNING INJECTION CAFFEOYLQUINIC ACIDS ALTERNATIVE MEDICINE ANTIVIRAL ACTIVITY MOLECULAR TARGETS VIRAL-INFECTIONS NITRIC-OXIDE IN-VITRO INFLUENZA
DOI	10.1039/c4mb00164h
英文摘要	Traditional Chinese medicine (TCM) is a multi-component and multi-target agent and could treat complex diseases in a holistic way, especially infection diseases. However, the underlying pharmacology remains unclear. Fortunately, network pharmacology by integrating system biology and polypharmacology provides a strategy to address this issue. In this work, Reduning Injection (RDN), a well-used TCM treatment in the clinic for upper respiratory tract infections (URTIs), was investigated to interpret the molecular mechanism and predict new clinical directions by integrating molecular docking, network analysis and cell-based assays. 32 active ingredients and 38 potential targets were identified. In vitro experiments confirmed the bioactivities of the compounds against lipopolysaccharide (LPS)-stimulated PGE(2) and NO production in RAW264.7 cells. Moreover, network analysis showed that RDN could not only inhibit viral replication but also alleviate the sickness symptoms of URTIs through directly targeting the key proteins in the respiratory viral life cycle and indirectly regulating host immune systems. In addition, other clinical applications of RDN such as neoplasms, cardiovascular diseases and immune system diseases were predicted on the basis of the relationships between targets and diseases.; Biochemistry & Molecular Biology; SCI(E); 4; ARTICLE; lirongchen@pku.edu.cn; xiaojxu@pku.edu.cn; xw_kanion@163.com; 10; 2517-2525; 10
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/217560]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhang, Xinzhuang,Gu, Jiangyong,Cao, Liang,et al. Network pharmacology study on the mechanism of traditional Chinese medicine for upper respiratory tract infection[J]. 分子生物系统,2014.
APA	Zhang, Xinzhuang.,Gu, Jiangyong.,Cao, Liang.,Li, Na.,Ma, Yiming.,...&Xiao, Wei.(2014).Network pharmacology study on the mechanism of traditional Chinese medicine for upper respiratory tract infection.分子生物系统.
MLA	Zhang, Xinzhuang,et al."Network pharmacology study on the mechanism of traditional Chinese medicine for upper respiratory tract infection".分子生物系统 (2014).