Synthesis of PDON-b-PEG-b-PDON block copolymers and drug delivery system   thereof

doi:10.1002/(SICI)1097-4628(19980627)68:13&lt;2121::AID-APP8&gt;3.0.CO;2-E

CORC > 北京大学 > 化学与分子工程学院

	Synthesis of PDON-b-PEG-b-PDON block copolymers and drug delivery system thereof
	Wang, H ; Dong, JH ; Qiu, KY ; Gu, ZW
刊名	应用聚合物科学杂志
	1998
关键词	1,4-dioxan-2-one poly(ethylene glycol) ABA block copolymer drug delivery system POLY(ETHYLENE GLYCOL) DEGRADATION POLYMERS LACTIDE
DOI	10.1002/(SICI)1097-4628(19980627)68:13<2121::AID-APP8>3.0.CO;2-E
英文摘要	ABA-type block copolymers of poly(1,4-dioxan-2-one) (PDON) with poly(ethylene glycol) (PEG) were synthesized and characterized. From the results of differential scanning calorimetry and wide-angle X-ray diffraction, it was observed that the PDON blocks show similar crystallization behavior with homopolymer while the PEG blocks demonstrate lower melting temperature and crystallinity than PEG homopolymer. Their dynamic contact angles (theta(alpha)) decreased with the increase of PEG fraction in copolymers, indicating the hydrophilicity of PDON-b-PEG-b-PDON (PDPEPD) copolymers was improved gradually. The potential application of PDPEPD copolymers in the drug delivery system has been investigated. The release rate of Levonorgestrel (LNG) increased with the strengthening of hydrophilicity of copolymer samples. The burst effect of release of LNG is small in copolymers with short PDON blocks. When DON mole fraction in copolymers is high enough, no burst effect can be observed. In an experimental period of about 25 days, the release rate of LNG kept almost constant. (C) 1998 John Wiley & Sons, Inc.; Polymer Science; SCI(E); EI; 23; ARTICLE; 13; 2121-2128; 68
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/216662]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Wang, H,Dong, JH,Qiu, KY,et al. Synthesis of PDON-b-PEG-b-PDON block copolymers and drug delivery system thereof[J]. 应用聚合物科学杂志,1998.
APA	Wang, H,Dong, JH,Qiu, KY,&Gu, ZW.(1998).Synthesis of PDON-b-PEG-b-PDON block copolymers and drug delivery system thereof.应用聚合物科学杂志.
MLA	Wang, H,et al."Synthesis of PDON-b-PEG-b-PDON block copolymers and drug delivery system thereof".应用聚合物科学杂志 (1998).