Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures | |
Song, Bo ; Sun, Qian ; Li, Haikuo ; Ge, Baosheng ; Pan, Ji Sheng ; Wee, Andrew Thye Shen ; Zhang, Yong ; Huang, Shaohua ; Zhou, Ruhong ; Gao, Xingyu ; Huang, Fang ; Fang, Haiping | |
刊名 | angewandte chemie international edition
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2014 | |
关键词 | aluminum aluminum-related diseases peptides protein denaturation ALZHEIMERS-DISEASE ALPHA-SYNUCLEIN PROGRAM PACKAGE ACCUMULATION DIALYSIS BINDING HYDROXIDE ENERGY VIRUS BRAIN |
DOI | 10.1002/anie.201307955 |
英文摘要 | A combination of ab initio calculations, circular dichroism, nuclear magnetic resonance, and X-ray photoelectron spectroscopy has shown that aluminum ions can induce the formation of backbone ring structures in a wide range of peptides, including neurodegenerative disease related motifs. These ring structures greatly destabilize the protein and result in irreversible denaturation. This behavior benefits from the ability of aluminum ions to form chemical bonds simultaneously with the amide nitrogen and carbonyl oxygen atoms on the peptide backbone.; Chemistry, Multidisciplinary; SCI(E); EI; 0; ARTICLE; bosong@sinap.ac.cn; xingyugao@sinap.ac.cn; fhuang@upc.edu.cn; 25; 6357-6363; 53 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/212404] ![]() |
专题 | 化学与分子工程学院 |
推荐引用方式 GB/T 7714 | Song, Bo,Sun, Qian,Li, Haikuo,et al. Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures[J]. angewandte chemie international edition,2014. |
APA | Song, Bo.,Sun, Qian.,Li, Haikuo.,Ge, Baosheng.,Pan, Ji Sheng.,...&Fang, Haiping.(2014).Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures.angewandte chemie international edition. |
MLA | Song, Bo,et al."Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures".angewandte chemie international edition (2014). |
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