Irreversible Denaturation of Proteins through Aluminum-Induced Formation   of Backbone Ring Structures

doi:10.1002/anie.201307955

CORC > 北京大学 > 化学与分子工程学院

	Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures
	Song, Bo ; Sun, Qian ; Li, Haikuo ; Ge, Baosheng ; Pan, Ji Sheng ; Wee, Andrew Thye Shen ; Zhang, Yong ; Huang, Shaohua ; Zhou, Ruhong ; Gao, Xingyu ; Huang, Fang ; Fang, Haiping
刊名	angewandte chemie international edition
	2014
关键词	aluminum aluminum-related diseases peptides protein denaturation ALZHEIMERS-DISEASE ALPHA-SYNUCLEIN PROGRAM PACKAGE ACCUMULATION DIALYSIS BINDING HYDROXIDE ENERGY VIRUS BRAIN
DOI	10.1002/anie.201307955
英文摘要	A combination of ab initio calculations, circular dichroism, nuclear magnetic resonance, and X-ray photoelectron spectroscopy has shown that aluminum ions can induce the formation of backbone ring structures in a wide range of peptides, including neurodegenerative disease related motifs. These ring structures greatly destabilize the protein and result in irreversible denaturation. This behavior benefits from the ability of aluminum ions to form chemical bonds simultaneously with the amide nitrogen and carbonyl oxygen atoms on the peptide backbone.; Chemistry, Multidisciplinary; SCI(E); EI; 0; ARTICLE; bosong@sinap.ac.cn; xingyugao@sinap.ac.cn; fhuang@upc.edu.cn; 25; 6357-6363; 53
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/212404]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Song, Bo,Sun, Qian,Li, Haikuo,et al. Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures[J]. angewandte chemie international edition,2014.
APA	Song, Bo.,Sun, Qian.,Li, Haikuo.,Ge, Baosheng.,Pan, Ji Sheng.,...&Fang, Haiping.(2014).Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures.angewandte chemie international edition.
MLA	Song, Bo,et al."Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures".angewandte chemie international edition (2014).