Progress in the study on the composition and formation: mechanism of   gallstone

doi:10.1007/BF02880673

CORC > 北京大学 > 化学与分子工程学院

	Progress in the study on the composition and formation: mechanism of gallstone
	Sun, Y ; Yang, ZL ; Shen, GR ; Zhou, Y ; Zhou, XS ; Wu, JG ; Xu, GX
刊名	中国科学b辑化学英文版
	2001
关键词	gallstone mechanism of formation periodic precipitation fractal pattern bile salts BILE-SALT SYSTEM PIGMENT GALLSTONES CHAOTIC PRECIPITATION EPR SPECTROSCOPY BILIRUBIN MODEL GEL
DOI	10.1007/BF02880673
英文摘要	Our serial studies from 1970s on chemical composition, structure determination and formation mechanism of gallstones were reviewed. The chemical component investigation of brown-pigment gallstone demonstrated that it consists of macromolecules such as proteins, glycoproteins, polysaccharides, bilirubin polymers and pigment polymers, and biomolecules such as cholesterol, bile salts, calcium salts of carbonate, phosphate, fatty acids and bilirubinate as well as various metal ions. The binding of metal ions with bile salts and bilirubin plays important roles in gallstone formation, i.e., calcium bilirubinate complex is:the major constitute of brown-pigment gallstones, and copper bilirubinate complex is critical in the black color appearance of black-pigment gallstone. The cross section of many gallstones exhibits a concentric ring structure composed of various small particles with a fractal character. This is nonlinear phenomenon in gallstone formation. A typical model system of metal ions-deoxycholate (or cholate)-gel was chosen to mimic an in vitro pattern formation system. The experimental results suggested that a nonlinear scientific concept should be considered in understanding gallstone formation. Minor changes in the chemical composition and/or the microenvironment may lead to very different precipitate patterns: with a variety of shapes, colors, appearances, and structures. A new model was suggested that periodical templets of periodical and fractal patterns were formed in the initial stage, then the spatio-temporal patterns grew gradually on it. Furthermore, the interaction between divalent metal ions and bile salts in vitro was investigated, and the results indicated that non-stoichiometric M(DC)(2)-NaDC mixed complexes with mixed micelles structure can be formed in physiological condition.; Chemistry, Multidisciplinary; SCI(E); EI; 4; ARTICLE; 5; 449-456; 44
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/211400]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Sun, Y,Yang, ZL,Shen, GR,et al. Progress in the study on the composition and formation: mechanism of gallstone[J]. 中国科学b辑化学英文版,2001.
APA	Sun, Y.,Yang, ZL.,Shen, GR.,Zhou, Y.,Zhou, XS.,...&Xu, GX.(2001).Progress in the study on the composition and formation: mechanism of gallstone.中国科学b辑化学英文版.
MLA	Sun, Y,et al."Progress in the study on the composition and formation: mechanism of gallstone".中国科学b辑化学英文版 (2001).