Salt and pH-dependent properties of native and mutant insulin

doi:10.1360/02tb9107

CORC > 北京大学 > 化学与分子工程学院

	Salt and pH-dependent properties of native and mutant insulin
	Ma, XH ; Li, CH ; Lu, BZ ; Chen, WZ ; Wang, CX ; Xu, XJ
刊名	科学通报英文版
	2002
关键词	formal charge electrostatic interaction insulin Poisson-Boltzmann equation PROTEINS SOLVENT
DOI	10.1360/02tb9107
英文摘要	A fast and effective model for predicting the salt and pH dependent properties of protein complexes is presented. It is based on the formal charge parameter sets of ionizable groups and applied in conjunction with the finite difference Poisson-Boltzmann (FDPB) method to calculate the electrostatic interactions. All simulations were performed on the native 2Zn insulin and its fast-acting mutants such as B9D (B9Ser --> Asp), B9E (B9Aer --> Glu), B9EB10D (B9Ser Glu, B10His --> Asp), and B10D (B10His --> Asp). The salt and pH dependent properties of these dimers were analyzed from the aspect of electrostatic interaction, and the theoretical basis of the fast-acting behavior of these mutants was explained. It is found that the results agree well with experimental observations.; Multidisciplinary Sciences; SCI(E); 1; ARTICLE; 6; 464-466; 47
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/209800]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Ma, XH,Li, CH,Lu, BZ,et al. Salt and pH-dependent properties of native and mutant insulin[J]. 科学通报英文版,2002.
APA	Ma, XH,Li, CH,Lu, BZ,Chen, WZ,Wang, CX,&Xu, XJ.(2002).Salt and pH-dependent properties of native and mutant insulin.科学通报英文版.
MLA	Ma, XH,et al."Salt and pH-dependent properties of native and mutant insulin".科学通报英文版 (2002).