Synthesis of an enzyme-like imprinted polymer with the substrate as the   template, and its catalytic properties under aqueous conditions

doi:10.1002/chem.200305370

CORC > 北京大学 > 化学与分子工程学院

	Synthesis of an enzyme-like imprinted polymer with the substrate as the template, and its catalytic properties under aqueous conditions
	Cheng, ZY ; Zhang, LW ; Li, YZ
刊名	chemistry a european journal
	2004
关键词	catalysts enzyme models hemin homovanillic acid peroxidase-like activity substrate-imprinted polymer SOL-GEL PROCESS HYDROGEN-PEROXIDE FLUOROMETRIC DETERMINATION MOLECULAR RECOGNITION IRON(III) PORPHYRINS OXIDATIVE ENZYMES METALLOPORPHYRINS DEGRADATION HEME ACID
DOI	10.1002/chem.200305370
英文摘要	Transition state analogues (TSAs) have long been regarded as ideal templates for the preparation of catalytically active synthetic imprinted polymers. In the current work, however, a new type of molecularly imprinted polymer (MIP) was synthesized with the substrate (homovanillic acid, HVA) as the template and hemin introduced as the catalytic center, with the use of plural functional monomers to prepare the active sites. The MIP successfully mimicked natural peroxidase, suggesting that it may not be imperative to employ a TSA as the template when preparing enzyme-like imprinted polymers and that the imprinted polymer matrix provided an advantageous microenvironment around the catalytic center (hemin), essentially similar to that supplied by apo-proteins in natural enzymes. Significantly, by taking advantage of the special structure of hemin and multiple-site interactions provided by several functional monomers, the intrinsic difficulties for MIPs in recognizing template molecules in polar solutions were overcome. The newly developed polymer showed considerable recognizing ability toward HVA, catalytic activity, substrate specificity and also stability, which are the merits lacked by the natural peroxidase. Meanwhile, the ease of recovery and reuse the MIP implies the potential for industrial application.; Chemistry, Multidisciplinary; SCI(E); EI; PubMed; 34; ARTICLE; 14; 3555-3561; 10
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/200302]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Cheng, ZY,Zhang, LW,Li, YZ. Synthesis of an enzyme-like imprinted polymer with the substrate as the template, and its catalytic properties under aqueous conditions[J]. chemistry a european journal,2004.
APA	Cheng, ZY,Zhang, LW,&Li, YZ.(2004).Synthesis of an enzyme-like imprinted polymer with the substrate as the template, and its catalytic properties under aqueous conditions.chemistry a european journal.
MLA	Cheng, ZY,et al."Synthesis of an enzyme-like imprinted polymer with the substrate as the template, and its catalytic properties under aqueous conditions".chemistry a european journal (2004).