Iodination and radiolabeling of alpha-allocryptopine with iodine-125

doi:10.1016/j.apradiso.2004.05.077

CORC > 北京大学 > 化学与分子工程学院

	Iodination and radiolabeling of alpha-allocryptopine with iodine-125
	Wei, Y ; Wei, XH ; Wang, Y ; Liu, XQ ; Chu, TW ; Hu, SW ; Wang, XY
刊名	应用辐射与同位素
	2005
关键词	alpha-allocryptopine iodination ICI 1-125 labeling exchange biodistribution PROTEIN-KINASE-C IODINE MONOCHLORIDE RADIOIODINATION ALKALOIDS TRANSPORTER LIGAND CHELERYTHRINE DERIVATIVES RECEPTORS CHLORIDE
DOI	10.1016/j.apradiso.2004.05.077
英文摘要	A procedure for labeling of a-allocryptopine with I-125 is reported in this article. alpha-allocryptopine is first iodinated with largely excessive iodine monochloride, and then radiolabeled by isotopic exchange with (NaI)-I-125 in a dichloromethane-water two-phase system. The radiochernical purity and yield of the labeled product are typically as high as 94% and 72%, respectively. Further chromatographic purification gives a highly pure product (radiochemical purity > 99%). The distribution of I-125-labeled alpha-allocryptopine in mice at 2h after injection shows that the uptake of radioiodine in thyroid is negligibly low. (C) 2004 Elsevier Ltd. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000225204000008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Inorganic & Nuclear; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging; SCI(E); EI; PubMed; 4; ARTICLE; 1; 55-62; 62
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/199934]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Wei, Y,Wei, XH,Wang, Y,et al. Iodination and radiolabeling of alpha-allocryptopine with iodine-125[J]. 应用辐射与同位素,2005.
APA	Wei, Y.,Wei, XH.,Wang, Y.,Liu, XQ.,Chu, TW.,...&Wang, XY.(2005).Iodination and radiolabeling of alpha-allocryptopine with iodine-125.应用辐射与同位素.
MLA	Wei, Y,et al."Iodination and radiolabeling of alpha-allocryptopine with iodine-125".应用辐射与同位素 (2005).