La3+-Promoted proliferation is interconnected with apoptosis in NIH 3T3   cells

doi:10.1002/jcb.20303

CORC > 北京大学 > 化学与分子工程学院

	La3+-Promoted proliferation is interconnected with apoptosis in NIH 3T3 cells
	Yu, SW ; Yuan, L ; Yang, XD ; Wang, K ; Ke, Y ; Qian, ZM
刊名	细胞生物化学杂志
	2005
关键词	La3+ proliferation apoptosis cell cycle ERK CELL-CYCLE PROGRESSION RARE-EARTH-ELEMENTS DNA-SYNTHESIS LANTHANUM IONS EXPRESSION CALCIUM GROWTH MEMBRANE CADMIUM MACROPHAGES
DOI	10.1002/jcb.20303
英文摘要	Lanthanum ion (La3+) has been reported to affect proliferation or apoptosis of different cells. In the present study, La3+ was confirmed to promote both proliferation and apoptosis of NIH 3T3 cells at the same concentrations. La3+ was shown to promote proliferation by helping the cells to pass through the G1/S restriction point and enter S phase, however, the proliferating cells induced by incubation with La3+ eventually underwent apoptosis. The proliferation and apoptosis of NIH 3T3 cells induced by La3+ were well correlated with cell cycle alterations. La3+ caused the phosphorylation of extracellular signal-regulated kinase (ERK) 1/2; while inhibition of ERK phosphorylation by 2'-amino-3'-methoxyflavone (PD98059) suppressed both proliferation and apoptosis induced by La3+. Based on the above experimental results, we postulated that La3+ promoted proliferation of NIH 3T3 cells Could be interconnected with the cell apoptosis, possibly through cell cycle machinery. Our results thus support the recent hypothesis that proliferation and apoptosis of cell are intrinsically coordinated. (C) 2004 Wiley-Liss, Inc.; Biochemistry & Molecular Biology; Cell Biology; SCI(E); PubMed; 0; ARTICLE; 3; 508-519; 94
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/199917]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Yu, SW,Yuan, L,Yang, XD,et al. La3+-Promoted proliferation is interconnected with apoptosis in NIH 3T3 cells[J]. 细胞生物化学杂志,2005.
APA	Yu, SW,Yuan, L,Yang, XD,Wang, K,Ke, Y,&Qian, ZM.(2005).La3+-Promoted proliferation is interconnected with apoptosis in NIH 3T3 cells.细胞生物化学杂志.
MLA	Yu, SW,et al."La3+-Promoted proliferation is interconnected with apoptosis in NIH 3T3 cells".细胞生物化学杂志 (2005).