La3+-Promoted proliferation is interconnected with apoptosis in NIH 3T3 cells | |
Yu, SW ; Yuan, L ; Yang, XD ; Wang, K ; Ke, Y ; Qian, ZM | |
刊名 | 细胞生物化学杂志
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2005 | |
关键词 | La3+ proliferation apoptosis cell cycle ERK CELL-CYCLE PROGRESSION RARE-EARTH-ELEMENTS DNA-SYNTHESIS LANTHANUM IONS EXPRESSION CALCIUM GROWTH MEMBRANE CADMIUM MACROPHAGES |
DOI | 10.1002/jcb.20303 |
英文摘要 | Lanthanum ion (La3+) has been reported to affect proliferation or apoptosis of different cells. In the present study, La3+ was confirmed to promote both proliferation and apoptosis of NIH 3T3 cells at the same concentrations. La3+ was shown to promote proliferation by helping the cells to pass through the G1/S restriction point and enter S phase, however, the proliferating cells induced by incubation with La3+ eventually underwent apoptosis. The proliferation and apoptosis of NIH 3T3 cells induced by La3+ were well correlated with cell cycle alterations. La3+ caused the phosphorylation of extracellular signal-regulated kinase (ERK) 1/2; while inhibition of ERK phosphorylation by 2'-amino-3'-methoxyflavone (PD98059) suppressed both proliferation and apoptosis induced by La3+. Based on the above experimental results, we postulated that La3+ promoted proliferation of NIH 3T3 cells Could be interconnected with the cell apoptosis, possibly through cell cycle machinery. Our results thus support the recent hypothesis that proliferation and apoptosis of cell are intrinsically coordinated. (C) 2004 Wiley-Liss, Inc.; Biochemistry & Molecular Biology; Cell Biology; SCI(E); PubMed; 0; ARTICLE; 3; 508-519; 94 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/199917] ![]() |
专题 | 化学与分子工程学院 |
推荐引用方式 GB/T 7714 | Yu, SW,Yuan, L,Yang, XD,et al. La3+-Promoted proliferation is interconnected with apoptosis in NIH 3T3 cells[J]. 细胞生物化学杂志,2005. |
APA | Yu, SW,Yuan, L,Yang, XD,Wang, K,Ke, Y,&Qian, ZM.(2005).La3+-Promoted proliferation is interconnected with apoptosis in NIH 3T3 cells.细胞生物化学杂志. |
MLA | Yu, SW,et al."La3+-Promoted proliferation is interconnected with apoptosis in NIH 3T3 cells".细胞生物化学杂志 (2005). |
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