Antiviral compounds from traditional Chinese medicines Galla chinese as   inhibitors of HCVNS3 protease

doi:10.1016/j.bmcl.2004.09.067

CORC > 北京大学 > 化学与分子工程学院

	Antiviral compounds from traditional Chinese medicines Galla chinese as inhibitors of HCVNS3 protease
	Duan, DL ; Li, ZQ ; Luo, HP ; Zhang, W ; Chen, LR ; Xu, XJ
刊名	生物有机化学与医药化学通讯
	2004
关键词	Galla chinese polyphenol inhibitor HCVNS3 protease TANNINS ACID POLYGALLOYLGLUCOSES DERIVATIVES PROTEINASE
DOI	10.1016/j.bmcl.2004.09.067
英文摘要	Under the guidance of bioassay, the EtOAc extract fraction of the Traditional Chinese Medicine (TCM) Galla Chinese was found to be efficient in inhibiting the NS3 protease of HCV and purified the fraction to get three polyphenol compounds 1,2,6-tri-O-galloyl-beta-D-glucose (1), 1.2,3,6-tetra-O-galloyl-beta-D-glucose (2), and 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (3), which were identified as inhibitors of Hepatitis C Virus (HCV) NS3 protease. Compounds 1, 2, and 3 inhibited HCV NS3 protease with IC50 of 1.89, 0.75, and 1.60 muM. respectively. (C) 2004 Elsevier Ltd. All rights reserved.; Chemistry, Medicinal; Chemistry, Organic; SCI(E); PubMed; 32; ARTICLE; 24; 6041-6044; 14
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/199911]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Duan, DL,Li, ZQ,Luo, HP,et al. Antiviral compounds from traditional Chinese medicines Galla chinese as inhibitors of HCVNS3 protease[J]. 生物有机化学与医药化学通讯,2004.
APA	Duan, DL,Li, ZQ,Luo, HP,Zhang, W,Chen, LR,&Xu, XJ.(2004).Antiviral compounds from traditional Chinese medicines Galla chinese as inhibitors of HCVNS3 protease.生物有机化学与医药化学通讯.
MLA	Duan, DL,et al."Antiviral compounds from traditional Chinese medicines Galla chinese as inhibitors of HCVNS3 protease".生物有机化学与医药化学通讯 (2004).