Synthesis and in vitro and in vivo evaluation of three radioiodinated   nitroimidazole analogues as tumor hypoxia markers

doi:10.1016/j.nucmedbio.2005.01.004

CORC > 北京大学 > 化学与分子工程学院

	Synthesis and in vitro and in vivo evaluation of three radioiodinated nitroimidazole analogues as tumor hypoxia markers
	Li, ZJ ; Chu, TW ; Liu, XQ ; Wang, XY
刊名	核医学与生物学
	2005
关键词	nitroimidazole iodine 131 hypoxia tumor biodistribution POSITRON-EMISSION-TOMOGRAPHY TC-99M-LABELED 2-NITROIMIDAZOLE RESISTANCE MECHANISMS IMAGING HYPOXIA RADIOSENSITIZERS MISONIDAZOLE DERIVATIVES TISSUE PHARMACOKINETICS BIODISTRIBUTION
DOI	10.1016/j.nucmedbio.2005.01.004
英文摘要	Three novel nitroimidazole-based thioflavin-T derivatives, N-[4-(benzothiazol-2-yl)phenyl]-3-(4-nitroimidazole-1-yl)propanarnide, N-[4(benzothiazol-2-yl) phenyl]-3-(4-nitroimidazole-1-yl)-N-methylpropanamide and N-[4-(benzothiazol-2-yl)phenyl]-3-(2-nitroimidazole-1-yl) propanamide were synthesized and radiolabeled with lodine-131. Three I-131-labeled compounds continuously accumulated in hypoxic murine sarcoma S180cells in vitro but not in aerobic cells. Biodistribution results in rnicebearing S180 turner indicated that the tracers could localize in the tumor and eliminate from it slowly. In contrast, the uptake in other organs (stomach excluded) was little and the clearance was quick. The tumor-to-tissue ratios of three compounds all increased with time. (c) 2005 Elsevier Inc. All rights reserved.; Radiology, Nuclear Medicine & Medical Imaging; SCI(E); PubMed; 23; ARTICLE; 3; 225-231; 32
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/199794]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Li, ZJ,Chu, TW,Liu, XQ,et al. Synthesis and in vitro and in vivo evaluation of three radioiodinated nitroimidazole analogues as tumor hypoxia markers[J]. 核医学与生物学,2005.
APA	Li, ZJ,Chu, TW,Liu, XQ,&Wang, XY.(2005).Synthesis and in vitro and in vivo evaluation of three radioiodinated nitroimidazole analogues as tumor hypoxia markers.核医学与生物学.
MLA	Li, ZJ,et al."Synthesis and in vitro and in vivo evaluation of three radioiodinated nitroimidazole analogues as tumor hypoxia markers".核医学与生物学 (2005).