A Concise and Diversity-Oriented Approach to the Synthesis of SAG   Derivatives

doi:10.1021/cc800025n

CORC > 北京大学 > 化学与分子工程学院

	A Concise and Diversity-Oriented Approach to the Synthesis of SAG Derivatives
	Wang, Nengdong ; Xiang, Jing ; Ma, Zhibo ; Quan, Junmin ; Chen, Jiahua ; Yang, Zhen
刊名	journal of combinatorial chemistry
	2008
关键词	SOLID-PHASE SYNTHESIS HEDGEHOG SIGNAL-TRANSDUCTION CROSS-COUPLING REACTIONS COMBINATORIAL LIBRARIES PRIVILEGED STRUCTURES MENSCHUTKIN REACTION DRUG DISCOVERY CHEMICAL SPACE SMALL-MOLECULE SUZUKI
DOI	10.1021/cc800025n
英文摘要	An efficient and rapid solution-phase combinatorial synthesis of the SAG library was developed. The salient features for this library synthesis is the application of carbothioamide-derived palladacycle-catalyzed Suzuki coupling reactions for the parallel synthesis of a series of pyridine-based biaryl aldehydes under aerobic conditions and a direct N-alkylation of carbarnates using NaH as base in DMF in the presence of catalytic amount of water. The resultant library has been submitted to biological screening to evaluate their potential role in the regulation of Hedgehog pathway.; Chemistry, Applied; Chemistry, Medicinal; Chemistry, Multidisciplinary; SCI(E); PubMed; 0; ARTICLE; 6; 825-834; 10
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/197571]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Wang, Nengdong,Xiang, Jing,Ma, Zhibo,et al. A Concise and Diversity-Oriented Approach to the Synthesis of SAG Derivatives[J]. journal of combinatorial chemistry,2008.
APA	Wang, Nengdong,Xiang, Jing,Ma, Zhibo,Quan, Junmin,Chen, Jiahua,&Yang, Zhen.(2008).A Concise and Diversity-Oriented Approach to the Synthesis of SAG Derivatives.journal of combinatorial chemistry.
MLA	Wang, Nengdong,et al."A Concise and Diversity-Oriented Approach to the Synthesis of SAG Derivatives".journal of combinatorial chemistry (2008).