Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the   transcription of autophagy genes in response to oxidative stress induced   by a novel copper complex in HeLa cells

doi:10.4161/auto.28789

CORC > 北京大学 > 化学与分子工程学院

	Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells
	Zhong, Wu ; Zhu, Haichuan ; Sheng, Fugeng ; Tian, Yonglu ; Zhou, Jun ; Chen, Yingyu ; Li, Song ; Lin, Jian
刊名	autophagy
	2014
关键词	cHYF127c/Cu MAPK11 MAPK12 MAPK13 MAPK14 autophagy copper oxidative stress p38 mitogen-activated protein kinase transcription CANCER-CELLS MONITORING AUTOPHAGY ANTITUMOR-ACTIVITY METAL-COMPLEXES DEATH INHIBITOR APOPTOSIS COMPOUND THERAPY GENERATION
DOI	10.4161/auto.28789
英文摘要	Transition metal copper (Cu) can exist in oxidized or reduced states in cells, leading to cytotoxicity in cancer cells through oxidative stress. Recently, copper complexes are emerging as a new class of anticancer compounds. Here, we report that a novel anticancer copper complex (HYF127c/Cu) induces oxidative stress-dependent cell death in cancer cells. Further, transcriptional analysis revealed that oxidative stress elicits broad transcriptional changes of genes, in which autophagy-related genes are significantly changed in HYF127c/Cu-treated cells. Consistently, autophagy was induced in HYF127c/Cu-treated cells and inhibitors of autophagy promoted cell death induced by HYF127c/Cu. Further analysis identified that the MAPK11/12/13/14 (formerly known as p38 MAPK) pathway was also activated in HYF127c/Cu-treated cells. Meanwhile, the MAPK11/12/13/14 inhibitor SB203580 downregulated autophagy by inhibiting the transcription of the autophagy genes MAP1LC3B, BAG3, and HSPA1A, and promoted HYF127c/Cu-induced cell death. These data suggest that copper-induced oxidative stress will induce protective autophagy through transcriptional regulation of autophagy genes by activation of the MAPK11/12/13/14 pathway in HeLa cells.; Cell Biology; SCI(E); PubMed; 3; ARTICLE; lis@bmi.ac.cn; linjian@pku.edu.cn; 7; 1285-1300; 10
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/188988]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhong, Wu,Zhu, Haichuan,Sheng, Fugeng,et al. Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells[J]. autophagy,2014.
APA	Zhong, Wu.,Zhu, Haichuan.,Sheng, Fugeng.,Tian, Yonglu.,Zhou, Jun.,...&Lin, Jian.(2014).Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells.autophagy.
MLA	Zhong, Wu,et al."Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells".autophagy (2014).