Ir(III)-Catalyzed Aromatic C-H Bond Functionalization via Metal Carbene   Migratory Insertion

doi:10.1021/jo5023102

CORC > 北京大学 > 化学与分子工程学院

	Ir(III)-Catalyzed Aromatic C-H Bond Functionalization via Metal Carbene Migratory Insertion
	Xia, Ying ; Liu, Zhen ; Feng, Sheng ; Zhang, Yan ; Wang, Jianbo
刊名	journal of organic chemistry
	2015
关键词	ALPHA-DIAZOCARBONYL COMPOUNDS QUINOLINE N-OXIDES DIAZO-COMPOUNDS RH(III)-CATALYZED SYNTHESIS IRIDIUM(III) COMPLEXES RHODIUM CATALYSIS MILD CONDITIONS C-8 POSITION ACTIVATION AMIDATION
DOI	10.1021/jo5023102
英文摘要	Ir(III)-catalyzed coupling of aromatic C-H bonds with diazomalonates has been achieved successfully via a metal carbene migratory insertion process. With different types of carbamoyl directing groups, a wide range of arenes, including heteroarenes, can be used as substrates in this Ir(III)-catalyzed C-H functionalization reaction. Mono- and bisfunctionalized products can be obtained selectively simply by changing the number of equivalents of the diazo substrate. Moreover, when diazomalonates bearing one or two tert-butyl groups are used as the substrates, the C-H bond functionalization is followed by decarboxyation, leading to products with a -CH2CO2Me or -CH2CO2H moiety at the position ortho to the directing group. This reaction demonstrates that direct C-H activation and the metal carbene migratory insertion can be merged into one catalytic cycle with an Ir(III) complex as the catalyst.; Chemistry, Organic; SCI(E); EI; PubMed; 6; ARTICLE; wangjb@pku.edu.cn; 1; 223-236; 80
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/188497]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Xia, Ying,Liu, Zhen,Feng, Sheng,et al. Ir(III)-Catalyzed Aromatic C-H Bond Functionalization via Metal Carbene Migratory Insertion[J]. journal of organic chemistry,2015.
APA	Xia, Ying,Liu, Zhen,Feng, Sheng,Zhang, Yan,&Wang, Jianbo.(2015).Ir(III)-Catalyzed Aromatic C-H Bond Functionalization via Metal Carbene Migratory Insertion.journal of organic chemistry.
MLA	Xia, Ying,et al."Ir(III)-Catalyzed Aromatic C-H Bond Functionalization via Metal Carbene Migratory Insertion".journal of organic chemistry (2015).