Determination methods for the anticancer drug dicycloplatin, a supramolecule assembled through hydrogen bonding | |
Yang Xuqing ; Zheng Jianwei ; Song Qinghua ; Xie Fang ; Tang Jijun ; Chen Jia ; Wu Jianfeng ; Li Chunzheng ; Cui Weichuan ; Tang Youqi ; Xie Jianwei ; Zheng Jianqiang | |
刊名 | the analyst
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2015 | |
DOI | 10.1039/c4an02274b |
英文摘要 | Dicycloplatin is a new generation supramolecular platinum-containing anti-cancer drug. Due to its structure, it is difficult to differentiate dicycloplatin from physical mixtures of carboplatin and cyclobutane dicarboxylate, and confounding results may arise during drug characterization. To solve this problem, this study aims to provide a reliable and reproducible standard for the determination of dicycloplatin. A simple method for dicycloplatin quality control has been developed using X-ray powder diffraction (XRPD) and high performance liquid chromatography (HPLC). XRPD allowed the control of impurities and dissociation of the dicycloplatin active ingredient to less than 1%, and HPLC allowed the monitoring and control of the relative molar ratio of carboplatin and cyclobutane dicarboxylate within the purity range. The study proved for the first time that the dicycloplatin supramolecule is substantially different from a physical mixture of carboplatin and cyclobutane dicarboxylate.; SCI(E); PubMed; 0; ARTICLE; xiejw@bmi.ac.cn; xingdayaoye@163.com; 8; 2704-12; 140 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/188294] ![]() |
专题 | 化学与分子工程学院 |
推荐引用方式 GB/T 7714 | Yang Xuqing,Zheng Jianwei,Song Qinghua,et al. Determination methods for the anticancer drug dicycloplatin, a supramolecule assembled through hydrogen bonding[J]. the analyst,2015. |
APA | Yang Xuqing.,Zheng Jianwei.,Song Qinghua.,Xie Fang.,Tang Jijun.,...&Zheng Jianqiang.(2015).Determination methods for the anticancer drug dicycloplatin, a supramolecule assembled through hydrogen bonding.the analyst. |
MLA | Yang Xuqing,et al."Determination methods for the anticancer drug dicycloplatin, a supramolecule assembled through hydrogen bonding".the analyst (2015). |
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