Determination methods for the anticancer drug dicycloplatin, a supramolecule assembled through hydrogen bonding

doi:10.1039/c4an02274b

CORC > 北京大学 > 化学与分子工程学院

	Determination methods for the anticancer drug dicycloplatin, a supramolecule assembled through hydrogen bonding
	Yang Xuqing ; Zheng Jianwei ; Song Qinghua ; Xie Fang ; Tang Jijun ; Chen Jia ; Wu Jianfeng ; Li Chunzheng ; Cui Weichuan ; Tang Youqi ; Xie Jianwei ; Zheng Jianqiang
刊名	the analyst
	2015
DOI	10.1039/c4an02274b
英文摘要	Dicycloplatin is a new generation supramolecular platinum-containing anti-cancer drug. Due to its structure, it is difficult to differentiate dicycloplatin from physical mixtures of carboplatin and cyclobutane dicarboxylate, and confounding results may arise during drug characterization. To solve this problem, this study aims to provide a reliable and reproducible standard for the determination of dicycloplatin. A simple method for dicycloplatin quality control has been developed using X-ray powder diffraction (XRPD) and high performance liquid chromatography (HPLC). XRPD allowed the control of impurities and dissociation of the dicycloplatin active ingredient to less than 1%, and HPLC allowed the monitoring and control of the relative molar ratio of carboplatin and cyclobutane dicarboxylate within the purity range. The study proved for the first time that the dicycloplatin supramolecule is substantially different from a physical mixture of carboplatin and cyclobutane dicarboxylate.; SCI(E); PubMed; 0; ARTICLE; xiejw@bmi.ac.cn; xingdayaoye@163.com; 8; 2704-12; 140
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/188294]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Yang Xuqing,Zheng Jianwei,Song Qinghua,et al. Determination methods for the anticancer drug dicycloplatin, a supramolecule assembled through hydrogen bonding[J]. the analyst,2015.
APA	Yang Xuqing.,Zheng Jianwei.,Song Qinghua.,Xie Fang.,Tang Jijun.,...&Zheng Jianqiang.(2015).Determination methods for the anticancer drug dicycloplatin, a supramolecule assembled through hydrogen bonding.the analyst.
MLA	Yang Xuqing,et al."Determination methods for the anticancer drug dicycloplatin, a supramolecule assembled through hydrogen bonding".the analyst (2015).