Structural and functional characterization of tumor suppressors TIG3 and H-REV107

doi:10.1016/j.febslet.2015.04.002

CORC > 北京大学 > 化学与分子工程学院

	Structural and functional characterization of tumor suppressors TIG3 and H-REV107
	Wei Hejia ; Wang Lei ; Ren Xiaobai ; Yu Wenyu ; Lin Jian ; Jin Changwen ; Xia Bin
刊名	欧洲生化学会联合会快报
	2015
关键词	H-REV107,NMR,Solution structure,TIG3,Tumor suppressor
DOI	10.1016/j.febslet.2015.04.002
英文摘要	H-REV107-like family proteins TIG3 and H-REV107 are class II tumor suppressors. Here we report that the C-terminal domains (CTDs) of TIG3 and H-REV107 can induce HeLa cell death independently. The N-terminal domain (NTD) of TIG3 enhances the cell death inducing ability of CTD, while NTD of H-REV107 plays an inhibitory role. The solution structure of TIG3 NTD is very similar to that of H-REV107 in overall fold. However, the CTD binding regions on NTD are different between TIG3 and H-REV107, which may explain their functional difference. As a result, the flexible main loop of H-REV107, but not that of TIG3, is critical for its NTD to modulate its CTD in inducing cell death.Copyright ? 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.; SCI(E); PubMed; 0; ARTICLE; binxia@pku.edu.cn; 11; 1179-86; 589
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/188106]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Wei Hejia,Wang Lei,Ren Xiaobai,et al. Structural and functional characterization of tumor suppressors TIG3 and H-REV107[J]. 欧洲生化学会联合会快报,2015.
APA	Wei Hejia.,Wang Lei.,Ren Xiaobai.,Yu Wenyu.,Lin Jian.,...&Xia Bin.(2015).Structural and functional characterization of tumor suppressors TIG3 and H-REV107.欧洲生化学会联合会快报.
MLA	Wei Hejia,et al."Structural and functional characterization of tumor suppressors TIG3 and H-REV107".欧洲生化学会联合会快报 (2015).